The risk of coronavirus to healthcare providers during aerosol-generating procedures: A systematic review and meta-analysis.

Context: Several medical procedures are thought to increase the risk of transmission of infectious agents to health-care providers (HCPs) through an aerosol-generating mechanism.

Aims: Given the significant influenza and coronavirus pandemics that have occurred in the 20 and 21 century, including the current severe acute respiratory syndrome coronavirus 2 global pandemic, the objective of this analysis is to assess the occurrence of disease transmission to HCPs from the performance aerosol-generating procedures (AGPs).

Settings And Design: This was a systematic review and meta-analysis.

Subjects And Methods: We performed a systematic meta-analysis looking at the odds ratio (OR) of AGP, causing infection among HCPs. We searched the following databases: MEDLINE (PubMed), ProQuest, Cochrane databases, and the Gray literature (ClinicalTrials.gov and World Health Organization International Clinical Trials Registry Platform). In addition, we conducted nondatabase search activities. The search terms used were "MERS-CoV," "COVID," and "SARS" combined with "provider" or "healthcare provider."

Statistical Analysis Used: RevMan meta-analysis was used for statistical analysis.

Results: Following the search, we reviewed 880 studies, of which six studies were eligible. The estimated odd ratio utilizing a control group of HCPs who were exposed to AGP but did not develop the infection was 1.85 (95% confidence interval [CI]: 1.33, 2.57). The OR remained the same when we added another control group who, despite not being exposed to AGP, had developed the infection. The OR remained 1.85 (95% CI: 1.33, 2.55). However, there is an increase in the OR to 1.89 (95% CI: 1.38, 2.59) when we added HCPs who did not use adequate personal protective equipment (PPE) during the procedures to the total estimates.

Conclusions: The performance of AGP with inadequate PPE can result in an increased risk of disease transmission to HCWs.