AI Article Synopsis
Article Abstract
Aim: We conducted this systematic review and meta-analysis to investigate the efficacy and safety of gefapixant, a novel P2X3 receptor antagonist, in patients with chronic cough.
Methods: We searched four databases for randomized controlled trials (RCTs). We assessed the cough frequency, severity, total Leicester cough questionnaire (LCQ) score, and adverse events. We analyzed the data using Open Meta-Analyst and Review Manager Software.
Results: We included four unique studies (comprising five stand-alone RCTs) with 439 patients. Compared to placebo, gefapixant had positive anti-tussive effects by improving awake cough frequency (mean difference [MD] = -5.27, 95% confidence interval [CI] [-6.12, -4.42], < 0.00001), night cough frequency (MD = -3.71, 95% CI [-6.57, -0.85], = 0. 01), 24 h cough frequency (MD = -4.18, 95% CI [-5.01, -3.36], < 0.00001), cough severity using the Visual Analog Scale (MD = -13.36, 95% CI [-17.80, -8.92], < 0.00001), cough severity diary (MD = -0.88, 95% CI [-1.25, -0.51], < 0.00001), and total LCQ score (MD = 2.00, 95% CI [1.15, 2.86], = 0. 00001). Meta-regression analyses showed a positive correlation between the gefapixant dose and the incidence of any adverse event (relative risk [RR] = 0.239, 95% CI [0.093, 1.839], = 0.001) and incidence of adverse event related to treatment (RR = 0.520, 95% CI [0.117, 0.922], = 0.011).
Conclusions: In patient with chronic cough, gefapixant exhibits favorable anti-tussive outcomes by improving the cough frequency, severity, and quality of life. While gefapixant is largely tolerable, its side effects (notably taste alteration) are dose dependent.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109686 | PMC |
| http://dx.doi.org/10.4103/atm.ATM_417_20 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Risk factors and outcomes of postoperative extubation failure in children with fourth ventricular tumors: a case control study.
BMC Pediatr
December 2024
Pediatric Intensive Care Unit, Guangzhou Women and Children's Medical Center (Guangzhou Medical University), Guangzhou, Guangdong, 510030, China.
Background And Objective: Microsurgical resection of tumor is an important treatment for children with fourth ventricular tumors. There is a lack of data describing risk factors for postoperative extubation failure (EF) in these children. We aimed to identify risk factors for EF in children with fourth ventricular tumors and to determine the association between EF and clinical outcomes.
View Article and Find Full Text PDFPredicting the risk of pulmonary embolism in patients with tuberculosis using machine learning algorithms.
Eur J Med Res
December 2024
Department of Geriatric Respiratory and Critical Care, Anhui Geriatric Institute, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
Background: This study aimed to develop predictive models with robust generalization capabilities for assessing the risk of pulmonary embolism in patients with tuberculosis using machine learning algorithms.
Methods: Data were collected from two centers and categorized into development and validation cohorts. Using the development cohort, candidate variables were selected via the Recursive Feature Elimination (RFE) method.
The discrepant effect of blood glucose on the risk of early and late lung injury: a national cohort study.
BMC Pulm Med
December 2024
Department of Endocrinology and Metabolism, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518033, China.
Article Synopsis
- This study aimed to explore the link between glycemic control and lung health using data from 5,610 participants in the NHANES survey from 2007-2012, focusing on respiratory symptoms and lung function tests.
- Results indicated that a 1% increase in blood glucose was negatively correlated with lung function, leading to reduced forced expiratory volume (FEV1) and forced vital capacity (FVC), along with a higher risk of breathing difficulties and mortality for those with restrictive lung disease.
- Improved glycemic control was associated with early markers of lung damage, whereas poor control correlated with more severe lung dysfunction, emphasizing the importance of managing blood glucose levels for respiratory health.
Inhibitory effect of low-dose esketamine on cough induced by sufentanil during the induction of anesthesia and postoperative impact on mental health status: a prospective, single-center, randomized controlled trial.
BMC Anesthesiol
December 2024
Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Background: Intravenous administration of sufentanil during anesthesia induction induces cough (SIC), sometimes triggers a severe reaction. We wanted to investigate the inhibitory effect of low-dose esketamine on cough induced by sufentanil during the induction of general anesthesia, as well as its postoperative impact on mental status (MMSE score, RSS, and VAS-A).
Methods: A total of 256 adult patients were randomly allocated to receive either esketamine (Group EK) or normal saline (Group C).
Efficacy of behavioral cough suppression therapy for refractory chronic cough or unexplained chronic cough: a meta-analysis of randomized controlled trials.
Ther Adv Respir Dis
December 2024
Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai 200065, China.
Background: The efficacy of behavioral cough suppression therapy (BCST) for refractory chronic cough (RCC) and unexplained chronic cough (UCC) remains unclear due to limited evidence from small-scale single-center studies.
Objective: To compile and assess the quality of evidence from randomized controlled trials to evaluate the effectiveness of BCST.
Design: This study included randomized controlled studies and self-controlled studies related to BCST involving adult patients with RCC or UCC.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!