A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session5i9l9in6b401d23gsqj5clnf94c8ojvo): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@remsenmedia.com&api_key=81853a771c3a3a2c6b2553a65bc33b056f08&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 197

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 197
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 271
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1057
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3175
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Anti-inflammatory Eudesmane Sesquiterpenoids from . | LitMetric

Anti-inflammatory Eudesmane Sesquiterpenoids from .

J Nat Prod

State Key Laboratory of Drug Research and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.

Published: May 2021

Fourteen new eudesmane sesquiterpenoids (, -, -) and seven known analogues were isolated from the whole plant of . Their structures were elucidated by spectroscopic data analysis and comparison with published NMR data, and their absolute configurations were confirmed by X-ray diffraction experiments and TDDFT ECD calculation. Compounds - were identified as eudesmane acids, which represent a kind of lactone ring-opening eudesmane-type sesquiterpenes with an acetoxyl or a hydroxy group attached to C-9. Compounds and , and , and and are three pairs of epimers isomerized at C-3, C-5, and C-11, respectively. Compounds -, -, -, and could influence the proinflammatory phenotype of the M1 macrophage. Among them, compounds , , , , , and consistently exhibited anti-inflammatory effects, as evidenced by downregulating classic pro-inflammatory cytokines TNF-α, IL-12, IL-6, and IFN-γ in LPS-induced primary bone marrow derived M1 macrophages.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jnatprod.1c00177DOI Listing

Publication Analysis

Top Keywords

eudesmane sesquiterpenoids
8
anti-inflammatory eudesmane
4
sesquiterpenoids fourteen
4
fourteen eudesmane
4
sesquiterpenoids analogues
4
analogues isolated
4
isolated plant
4
plant structures
4
structures elucidated
4
elucidated spectroscopic
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!