When addressing semiparametric problems with parametric restrictions (assumptions on the distribution), the efficient score (ES) of a parameter is often important for generating useful estimates. However, usual derivation of ES, although conceptually simple, is often lengthy and with many steps that do not help in understanding why its final form arises. This drawback often casts onto semiparametric estimation a mantle that can turn away otherwise able doctoral students or researchers. Here we show that many ESs can be obtained as a one-step derivation after we characterize those features (envelopes) of the unrestricted problem that are constrained in the restricted problem. We demonstrate our arguments in three problems with known ES but whose usual derivations are lengthy. We show that the envelope-based derivation is dramatically explanatory and compact, needing essentially two lines where the standard approach needs 10 or more pages. This suggests that the envelope method can add useful intuition and exegesis to both teaching and research of semiparametric estimation.
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http://dx.doi.org/10.1515/ijb-2019-0043 | DOI Listing |
Microsyst Nanoeng
January 2025
Institute of Novel Semiconductors, State Key Laboratory of Crystal Materials, Shandong University, 27 South Shanda Road, Shandong, 250100, P. R. China.
Acoustic frequency combs (AFCs) contain equidistant coherent signals with unconventional possibilities on metrology. Previously, implementation of AFCs on mechanical microresonators with large air damping loss is difficult, which restricted their atmospheric applications. In this work, we explore the potentials of a composite diamond/silicon microcantilever for parametric generation of AFCs in ambient air.
View Article and Find Full Text PDFHeliyon
January 2025
Faculty of Sport Science, Ningbo University, Ningbo, 315211, China.
The long jump is an athletic event that demands speed, power, force application, and balance, with each phase being critical to overall performance. However, previous research has neglected the limiting effect of the wedge pedals on ankle dorsiflexion range of motion. This cross-sectional study investigated biomechanical changes in the lower extremities during long jumps under varying degrees of ankle dorsiflexion.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
January 2025
Institute for Community Medicine, Section Epidemiology of Health Care and Community Health, University Medicine Greifswald, 17489, Greifswald, Germany.
Introduction: The objective of this study is to compare the 5 year overall survival of patients with stage I-III colon cancer treated by laparoscopic colectomy versus open colectomy.
Methods: Using Mecklenburg-Western Pomerania Cancer Registry data from 2008 to 2018, we will emulate a phase III, multicenter, open-label, two-parallel-arm hypothetical target trial in adult patients with stage I-III colon cancer who received laparoscopic or open colectomy as an elective treatment. An inverse-probability weighted Royston‒Parmar parametric survival model (RPpsm) will be used to estimate the hazard ratio of laparoscopic versus open surgery after confounding factors are balanced between the two treatment arms.
J Cachexia Sarcopenia Muscle
February 2025
Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany.
Background: Despite a phenylalanine (Phe) restrictive diet, most adult patients with 'classical' phenylketonuria (PKU) maintain life-long Phe concentrations above the normal range and receive tyrosine (Tyr) and protein-enriched diets to maintain acceptable concentrations and ensure normal development. While these interventions are highly successful in preventing adverse neuropsychiatric complications, their long- term consequences are incompletely explored. We observed early cardiomyopathic characteristics and associated hemodynamic changes in adult PKU patients and present here the results of a longitudinal evaluation of cardiac phenotype.
View Article and Find Full Text PDFPLoS One
January 2025
Laboratory for Biomechanics and Biomaterials, Department of Orthopedic Surgery, DIAKOVERE Annastift, Hannover Medical School, Hannover, Germany.
Prosthetic gait differs considerably from the unimpaired gait. Studying alterations in the gait patterns could help to understand different adaptation mechanisms adopted by these populations. This study investigated the effects of induced stiff-knee gait (SKG) on prosthetic and healthy gait patterns and the capabilities of predictive simulation.
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