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Transepithelial Corneal Crosslinking Using a Novel Ultraviolet Light-Emitting Contact Lens Device: A Pilot Study. | LitMetric

Transepithelial Corneal Crosslinking Using a Novel Ultraviolet Light-Emitting Contact Lens Device: A Pilot Study.

Transl Vis Sci Technol

Albert Einstein College of Medicine, Montefiore Medical Center, Department of Ophthalmology and Visual Sciences, New York, USA.

Published: April 2021

AI Article Synopsis

  • A pilot study was conducted to assess the feasibility of a new on-eye UVA light-emitting contact lens device for corneal crosslinking in patients with keratoconus.
  • Nine patients with advanced keratoconus were treated using this device, with results analyzed for corneal measurements and visual acuity before and six months after treatment.
  • Findings showed a significant decrease in maximum keratometry; although other measures like visual acuity and corneal thickness changes were not significant, the study confirmed the device is promising for future research.

Article Abstract

Purpose: To evaluate the feasibility of a novel, on-eye UVA light-emitting contact lens device driven by fiber optics for the corneal crosslinking (CXL) of patients with keratoconus.

Methods: In nine corneal transplant candidates with advanced keratoconus a scleral contact lens reservoir containing 0.007% benzalkonium chloride preserved with 0.25% riboflavin-monophosphate was placed on the eye for 30 minutes. The reservoir lens was removed and replaced with the CXLens UVA light-emitting contact lens. A 375-nm UVA light at 4 mW/cm2 intensity was delivered for 30 minutes for a dose of 7.2 J/cm2. A one-sided paired t-test was used to evaluate mean differences in maximum keratometry, thinnest corneal thickness, and endothelial cell density between screening and 6 months after CXL. A two-sided paired t-test was used to evaluate differences in best-corrected distance visual acuity between screening and 6 months after CXL.

Results: All patients received the treatment as per protocol and adhered to follow-up testing. At 6 months after CXL, treated eyes had an average -1.0 ± 1.6 diopters decrease in the maximum keratometry (P = 0.049), a nonsignificant 2.3 ± 7.5 letter improvement in best-corrected distance visual acuity (P = 0.19), a nonsignificant -17 ± 14 µm decrease in thinnest corneal thickness (P < 0.01), and a nonsignificant -86 ± 266 cells/mm2 decrease in endothelial cell density (P = 0.20).

Conclusions: Our pilot study demonstrated the feasibility of the novel CXL device for the treatment of keratoconus and indicates the device is ready for larger scale studies with longer follow-up periods.

Translational Relevance: The novel CXLens on-eye UVA light-emitting contact lens device offers the potential for efficient, high-throughput transepithelial corneal CXL.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088220PMC
http://dx.doi.org/10.1167/tvst.10.5.5DOI Listing

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