AI Article Synopsis
- - A new, easy one-pot method has been developed for synthesizing 3,5-disubstituted-1,2,4-triazoles without using transition metals.
- - The process uses readily available 1,1-diaminoazines as starting materials, leading to a broader range of possible products.
- - This technique results in faster reactions and better yields than previously reported methods, with the mechanism involving nucleophilic addition and cyclization.
Article Abstract
A simple, convenient, transition metal-free one pot synthesis of 3,5-disubstituted-1,2,4-triazoles has been established. The innovation in this reaction is the use of easily available 1,1-diaminoazines as substrates. This method provides the products with wider substrate scope, at an expedited rate, and with relatively better yields in comparison to the reported methods. The reaction mechanism involves an initial intermolecular nucleophilic addition (facilitated by I) followed by intramolecular nucleophilic cyclization.
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| http://dx.doi.org/10.1021/acs.joc.1c00704 | DOI Listing |
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