Background: Sepsis is a life-threatening organic dysfunction caused by an unregulated host response to infection. Management includes a prompt antibiotic treatment. Incorrect treatment can negatively influence in survival.
Objective: To describe the pattern of antimicrobial resistance of the main isolated microorganisms in blood cultures of patients with sepsis in a reference center of Mexico City.
Material And Methods: Observational, retrospective, descriptive, cross-sectional study. Data from blood cultures performed in patients diagnosed with sepsis were analyzed during the period from January 1, 2015, to December 31, 2018.
Results: 450 positive blood cultures were identified. Escherichia coli (34.5%) and Staphylococcus aureus (24.4%) were the most frequently isolated bacteria. E. coli and Klebsiella pneumoniae showed resistance to third generation cephalosporins of 75 and 80%, respectively. For K. pneumoniae it was reported resistance to carbapenems in 12.7%. For Enterococcus faecium it was reported a resistance to vancomycin in 60%. Multidrug resistance within the group of non-fermenting bacteria was reported in 88.1% for Acinetobacter baumannii and 48.8% in Pseudomonas aeruginosa. The resistance to methicillin in S. aureus was 23.6%.
Conclusions: A high proportion of beta-lactamase producing Enterobacteriaceae was observed, as well as a higher proportion of multidrug-resistant non-fermenting bacteria.
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