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A high-performance core laboratory GFAP/UCH-L1 test for the prediction of intracranial injury after mild traumatic brain injury.
Am J Emerg Med
December 2024
Warfighter Readiness, Performance, and Brain Health Project Management Office (WRPBH PMO), US Army Medical Materiel Development Activity (USAMMDA), 1430 Veterans Drive, Fort Detrick, MD 21702, USA.
Article Synopsis
- A blood biomarker panel including GFAP and UCH-L1 can potentially replace head CT scans for certain patients with traumatic brain injury (TBI), as it shows high sensitivity and negative predictive values.
- In a study with 1,899 TBI patients, the panel accurately identified the presence of traumatic intracranial injury in most cases, with a low false-negative rate.
- The core lab-based platform allows for rapid analysis of multiple samples, which is particularly useful in urgent situations like mass casualty events or busy emergency departments.
Hemoadsorption therapy for myoglobin removal in rhabdomyolysis: consensus of the hemoadsorption in rhabdomyolysis task force.
BMC Nephrol
July 2024
Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, D-48149, Münster, Germany.
Background: Rhabdomyolysis describes a syndrome characterized by muscle necrosis and the subsequent release of creatine kinase and myoglobin into the circulation. Myoglobin elimination with extracorporeal hemoadsorption has been shown to effectively remove myoglobin from the circulation. Our aim was to provide best practice consensus statements developed by the Hemoadsorption in Rhabdomyolysis Task Force (HRTF) regarding the use of hemadsorption for myoglobin elimination.
View Article and Find Full Text PDFMobile PCR-based surveillance for SARS-CoV-2 to reduce visiting restrictions in nursing homes during the COVID-19 pandemic: a pilot study.
Infection
June 2022
Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, North Rhine-Westphalia, Germany.
Purpose: Residents in nursing homes for the elderly (NH) are at high risk for death from COVID-19. We investigated whether repeated non-mandatory RT-PCR SARS-CoV-2 surveillance of NH staff and visitors reduces COVID-19 incidence rates in NH residents and allows to reduce visiting restrictions.
Methods: This pilot study at the beginning of the COVID-19 pandemic compared a surveillance approach of regular, twice-weekly voluntary PCR testing of health-care workers (HCW) and visitors in interventional NH (INH) with a setting without regular testing in control NH (CNH).
Web-based, rapid and contactless management of ambulatory patients for SARS-CoV-2-testing.
BMC Infect Dis
June 2021
Department for Clinical affairs and Crisis management, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, 50973, Cologne, Germany.
Background: During the SARS-CoV-2 pandemic a mass casualty incident of ambulatory patients occurred at the COVID-19 rapid response infrastructure (CRRI) facility at the University Hospital of Cologne (UHC). We report the development of a patient-centred mobile-device solution to support efficient management of the facility, triage of patients and rapid delivery of test results.
Methods: The UHC-Corona Web Tool (CWT) was developed as a web-based software useable on each patient's smartphone.
Lecture No. 9 Investing in Asian healthcare market.
Jpn J Clin Oncol
May 2021
KPMG Healthcare Japan, Co., Ltd, Tokyo, Japan.
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