Application of multimodal MRI and radiologic features for stereotactic brain biopsy: insights from a series of 208 patients.

Br J Neurosurg

Department of Neurosurgery, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.

Published: October 2021

Objectives: We reviewed our institutional experience during a 10-year period for improvement of safety and efficacy of stereotactic biopsy procedures.

Methods: We performed a retrospective review of inpatient summaries, stereotactic worksheets and radiologic investigations of 208 consecutive patients, who underwent MRI-guided stereotactic biopsies between March 2010 and March 2020.

Results: The overall diagnostic yield was 96.2%. CT-confirmed intracranial hemorrhage occurred in 17 patients (8.2%), and the overall mortality rate was 0.5%. Combined MRS and PWI helped target selection in 27 cases (13.0%), the diagnostic yield was 100%. The results of the regression analysis revealed that non-diagnostic biopsy specimen significantly correlated with the cystic trait (<.01) and edema of lesions (<.05). Enhancement (<.01) is shown to be an important factor for obtaining a diagnostic biopsy. Furthermore, the edema trait of lesions (<.01) showed the important factors of hemorrhage.

Conclusions: The radiological features of lesions and use of the most suitable MRI sequences during biopsy planning are recommended ways to improve the diagnostic yield and safety of this technique.

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http://dx.doi.org/10.1080/02688697.2021.1926922DOI Listing

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