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http://dx.doi.org/10.1007/s43441-021-00305-9 | DOI Listing |
Brain Behav Immun Health
February 2025
Dept of Immunology, Erasmus Medical Center, Rotterdam, the Netherlands.
Background: A considerable proportion (21%) of patients with common variable immunodeficiency (CVID) suffers from depression. These subjects are characterized by reduced naïve T cells and a premature T cell senescence similar to that of patients with major depressive disorder (MDD). It is known that T cells are essential for limbic system development/function.
View Article and Find Full Text PDFCureus
December 2024
Faculty of Medicine, King Abdulaziz University, Jeddah, SAU.
Background Body dysmorphic disorder (BDD) is a psychiatric disorder characterized by excessive preoccupation with a perceived defect in one's appearance. Patients with BDD often seek cosmetic surgery to correct their perceived defect. Rhinoplasty is one of the most requested cosmetic surgeries.
View Article and Find Full Text PDFExp Astron (Dordr)
January 2025
Space Sciences Laboratory, University of California, Berkeley, 7 Gauss Way, Berkeley, 94720 CA USA.
We present an investigation into the effects of high-energy proton damage on charge trapping in germanium cross-strip detectors with the goal of accomplishing three important measurements. First, we calibrated and characterized the spectral resolution of a spare COSI-balloon detector in order to determine the effects of intrinsic trapping, finding that electron trapping due to impurities dominates over hole trapping in the undamaged detector. Second, we performed two rounds of proton irradiation of the detector in order to quantify, for the first time, the rate at which charge traps are produced by proton irradiation.
View Article and Find Full Text PDFStat Med
February 2025
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Introduction: Risk prediction models are increasingly used in healthcare to aid in clinical decision-making. In most clinical contexts, model calibration (i.e.
View Article and Find Full Text PDFProtein Sci
February 2025
Cell Physiology and Molecular Biophysics Department, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Purifying membrane proteins has been the limiting step for studying their structure and function. The challenges of the process include the low expression levels in heterologous systems and the requirement for their biochemical stabilization in solution. The human voltage-gated proton channel (hH1) is a good example of that: the published protocols to express and purify hH1 produce low protein quantities at high costs, which is an issue for systematically characterizing its structure and function.
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