This paper presents a method for automatic segmentation of tympanic membranes (TMs) from video-otoscopic images based on deep fully convolutional neural network. Built upon the UNet architecture, the proposed EAR scheme is based on three main paradigms: EfficientNet for the encoder, Attention gate for the skip connection path, and Residual blocks for the decoder. The paper also introduces a new loss function term for the neural networks to perform segmentation tasks. Particularly, we propose to integrate EfficientNet-B4 into the encoder part of the UNet. In addition, the decoder part of the proposed network is constructed based on residual blocks from ResNet architecture. By this way, the proposed approach could take advantages of the EfficientNet and ResNet architectures such as preserving efficient reception field size for the model and avoiding overfitting problem. In addition, in the skip connection path, we employ the attention gate that can handle the varieties in shapes and sizes of interested objects, which are common issues in TM regions. Moreover, for network training, we proposed a new loss function term based on the shape distance between predicted and ground truth masks, and exploited the stochastic weight averaging to avoid being trapped in local minima. We evaluate the proposed approach on a TM dataset which includes 1012 otoscopic images from patients diagnosed with and without otitis media. Experimental results show that the proposed approach achieves high segmentation performance with the average Dice similarity coefficient of 0.929, without any pre- or post-processing steps, that outperforms other state-of-the-art methods.
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http://dx.doi.org/10.1016/j.artmed.2021.102065 | DOI Listing |
CNS Drugs
January 2025
School of Medicine and Dentistry, Gold Coast Campus, Griffith University, Southport, QLD, 4222, Australia.
Background: Epstein-Barr virus (EBV) is implicated as a necessary factor in the development of multiple sclerosis (MS) and may also be a driver of disease activity. Although it is not clear whether ongoing viral replication is the driver for MS pathology, MS researchers have considered the prospect of using drugs with potential efficacy against EBV in the treatment of MS. We have undertaken scientific and lived experience expert panel reviews to shortlist existing licensed therapies that could be used in later-stage clinical trials in MS.
View Article and Find Full Text PDFMol Divers
January 2025
Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases Ministry of Education, Jiangxi Province Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering, Gannan Medical University, Ganzhou, 341000, Jiangxi, China.
Identifying drug-target binding affinity (DTA) plays a critical role in early-stage drug discovery. Despite the availability of various existing methods, there are still two limitations. Firstly, sequence-based methods often extract features from fixed length protein sequences, requiring truncation or padding, which can result in information loss or the introduction of unwanted noise.
View Article and Find Full Text PDFCarbon Balance Manag
January 2025
North Carolina State University, Raleigh, NC, USA.
Forests have the potential to contribute significantly to global climate policy efforts through enhanced carbon sequestration and storage in terrestrial systems and wood products. Projections models simulate changes future in forest carbon fluxes under different environmental, economic, and policy conditions and can inform landowners and policymakers on how to best utilize global forests for mitigating climate change. However, forest carbon modeling frameworks are often developed and applied in a highly disciplinary manner, e.
View Article and Find Full Text PDFVis Comput Ind Biomed Art
January 2025
School of Engineering Medicine and School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
Fluorescence endoscopy technology utilizes a light source of a specific wavelength to excite the fluorescence signals of biological tissues. This capability is extremely valuable for the early detection and precise diagnosis of pathological changes. Identifying a suitable experimental approach and metric for objectively and quantitatively assessing the imaging quality of fluorescence endoscopy is imperative to enhance the image evaluation criteria of fluorescence imaging technology.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.
A value is conventionally interpreted either as a) the probability by chance of obtaining more extreme results than those observed or b) a tool for declaring significance at a prespecified level. Both approaches carry difficulties: b) does not allow users to make inferences based on the data in hand, and is not rigorously followed by researchers in practice, while (a) is not meaningful as an error rate. Although values retain an important role, these shortcomings are likely to have contributed significantly to the scientific reproducibility crisis.
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