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Effects of Cannabidiol Isolated or in Association With Risperidone in an Animal Model of Autism.
Dev Neurobiol
January 2025
Laboratory of Autism and Neurodevelopmental Research, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, Santa Catarina, Brazil.
Autism spectrum disorder (ASD) is characterized by deficits in communication, social interaction, and repetitive and stereotyped behaviors, with no specific drug therapy available. Studies have found that cannabidiol (CBD) can improve hyperactive and cognitive symptoms in children with ASD. However, little is known about the effect of CBD in combination with other medications, such as risperidone (RISP).
View Article and Find Full Text PDFAntipsychotic Activity of Ethanolic Extracts of Crinum asiaticum and Crinum defixum in Animal Models.
Zhongguo Ying Yong Sheng Li Xue Za Zhi
October 2024
Sri Jaydev College of Pharmaceutical Sciences, Naharkanta, Bhubaneswar, Odisha-752101, India.
The current study examined the antipsychotic properties of ethanolic extracts of Crinum asiaticum (EECA) and Crinum defixum (EECD). The effects of the extracts on rodents' ketamine-induced hyperactivity, amphetamine-induced stereotypy, forced swim test, conditioned avoidance response, and catalepsy were assessed. According to the findings, EECA and EECD both significantly outperformed typical antipsychotic medications in antipsychotic-like behaviours across a variety of behavioural paradigms.
View Article and Find Full Text PDFImpact of 5-Lipoxygenase Deficiency on Dopamine-Mediated Behavioral Responses.
Neurotox Res
October 2024
Department of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
The 5-lipoxygenase/leukotriene system has been implicated in both physiological and pathological states within the central nervous system. Understanding how this system interacts with the dopaminergic system could provide valuable insights into dopamine-related pathologies. This study focused on examining both motor and non-motor dopamine-related responses in 5-lipoxygenase/leukotriene-deficient mice.
View Article and Find Full Text PDFEffective action of silymarin against ketamine-induced schizophrenia in male mice: Insight into the biochemical and molecular mechanisms of action.
J Psychiatr Res
November 2024
DELSU Joint Canada-Israel Neuroscience and Biopsychiatry Laboratory, Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria.
Background: Neurochemical dysregulations resulting from N-methyl-D-aspartate hypofunction (NMDA), are exacerbated by neuroimmune and oxidative stress and are known risk factors for neuropsychiatric disorders like schizophrenia-like diseases. Here, we investigate the protective and curative effects, and mechanisms of silymarin, a polyphenolic flavonoid with neuroprotective functions in preventive-reversal model of ketamine, an NMDA antagonist in mice.
Methods: Mice were grouped into 6 cohorts (n = 9).
SEP-363856 exerts neuroprotection through the PI3K/AKT/GSK-3β signaling pathway in a dual-hit neurodevelopmental model of schizophrenia-like mice.
Drug Dev Res
June 2024
Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, Anhui, China.
Article Synopsis
- Schizophrenia (SZ) is a serious neurodevelopmental disorder primarily treated with antipsychotics, and SEP-363856 is a new antipsychotic currently being studied that doesn't act on dopamine D receptors, but its mechanism is still unclear.
- The study involved creating an animal model of SZ using perinatal MK-801 treatment combined with social isolation, and various behavioral tests and molecular analyses were performed to assess the effects of SEP-856.
- Results showed that SEP-856 significantly improved symptoms in the SZ-like model by reducing hyperactivity, enhancing social interaction, and reversing other SZ-associated behaviors.
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