»: Acetaminophen is an effective addition to a multimodal pain regimen; however, evidence to support intravenous versus oral administration requires further evaluation.
»: While nonsteroidal anti-inflammatory drugs are a valuable addition to a multimodal pain strategy, concerns regarding their effect on healing after certain procedures (i.e., rotator cuff repair) in select patients may preclude their use.
»: The use of perioperative gabapentinoids have varied results for pain control, and additional research is warranted to support their use after certain shoulder procedures.
»: Opioid-prescribing should be limited and reserved for severe postoperative pain. When prescribed, opioids should be taken at the lowest possible dose and for the shortest period.
»: Centrally acting analgesics such as tramadol have been shown to be as effective as opioids and have a lower risk of complications.
»: Nerve blocks are an excellent addition to multimodal pain management strategies. Longer-lasting formulations of perioperative single-shot injections and indwelling catheters may reduce rebound pain.
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http://dx.doi.org/10.2106/JBJS.RVW.20.00191 | DOI Listing |
BMC Bioinformatics
January 2025
School of Computing and Artificial Intelligence, Southwest Jiaotong University, Chengdu, 611756, Sichuan, China.
Background: Drug response prediction is critical in precision medicine to determine the most effective and safe treatments for individual patients. Traditional prediction methods relying on demographic and genetic data often fall short in accuracy and robustness. Recent graph-based models, while promising, frequently neglect the critical role of atomic interactions and fail to integrate drug fingerprints with SMILES for comprehensive molecular graph construction.
View Article and Find Full Text PDFJ Am Soc Mass Spectrom
January 2025
Maastricht MultiModal Molecular Imaging Institute (M4i), Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
Drug toxicity during the development of candidate pharmaceuticals is the leading cause of discontinuation in preclinical drug discovery and development. Traditionally, the cause of the toxicity is often determined by histological examination, clinical pathology, and the detection of drugs and/or metabolites by liquid chromatography-mass spectrometry (LC-MS). While these techniques individually provide information on the pathological effects of the drug and the detection of metabolites, they cannot provide specific molecular spatial information without additional experiments.
View Article and Find Full Text PDFPLoS One
January 2025
Faculty of Science and Technology, University of Canberra, Canberra, ACT, Australia.
We explore the efficacy of multimodal behavioral cues for explainable prediction of personality and interview-specific traits. We utilize elementary head-motion units named kinemes, atomic facial movements termed action units and speech features to estimate these human-centered traits. Empirical results confirm that kinemes and action units enable discovery of multiple trait-specific behaviors while also enabling explainability in support of the predictions.
View Article and Find Full Text PDFJ Anat
January 2025
Department of Anatomy and Regenerative Medicine, Tissue Engineering Research Group (TERG) Royal College of Surgeons Ireland (RCSI) University of Medicine and Health Sciences, Dublin, Ireland.
According to the World Health Organization (WHO) musculoskeletal conditions are a leading contributor to disability worldwide. This fact is often somewhat overlooked, since musculoskeletal conditions are less likely to be associated with mortality. Nonetheless, treatments, therapies and management of these conditions are extremely costly to national healthcare systems.
View Article and Find Full Text PDFNanoscale
January 2025
Tang Center of Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL, 60637, USA.
Obesity, a chronic metabolic disorder characterized by excessive body weight and adipose tissue accumulation, is intricately linked to a spectrum of health complications. It is driven by a confluence of factors, including gut microbiota dysbiosis, inflammation, and oxidative stress, which are pivotal in its pathogenesis. A multifaceted therapeutic strategy that targets these interrelated pathways is essential for effective obesity management.
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