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[Antibioprophylaxis failure with BCG therapy for bladder neoplasia].

Rev Mal Respir

December 2024

Service de pneumologie et explorations fonctionnelles respiratoires, CHRU de Tours, Tours, France; UMR 1100, université François-Rabelais, Tours, France; Inserm, centre d'étude des pathologies respiratoires, UMR 1100/EA6305, Tours, France. Electronic address:

Introduction: BCG therapy is the standard treatment for bladder tumors that do not infiltrate smooth muscle. Fluoroquinolones for antibiotic prophylaxis are recommended to lessen the risk of BCG infection (BCGitis) with respiratory involvement.

Case Report: This study describes five cases of BCGitis in males, with a median age of 71years [range: 66-77years] having undergone ofloxacin prophylaxis during their BCG therapy for a non-invasive bladder tumor (grade pT1a).

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Introduction: Candida albicans infection shows a wide range of patterns on chest computed tomography, including ground glass opacities and consolidation, with the miliary pattern being the least frequent. The miliary pattern is not exclusive to tuberculosis. Fungal lung infections are rare and potentially fatal.

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Disseminated histoplasmosis from western Mexico-rethinking our geographic distribution of endemic fungal species: a case report and review of literature.

J Med Case Rep

November 2024

Division of Pediatric Infectious Diseases, Memorial Care Miller Children's & Women's Hospital Long Beach, Clinical Professor of Pediatrics, University of California Irvine Department of Pediatrics, Irvine, CA, USA.

Background: Histoplasma is a fungal pathogen found in many parts of the world. In North America, its distribution is traditionally thought to be endemic to the Ohio and Mississippi River valleys. Development of histoplasmosis after Histoplasma exposure is related to degree of inoculum exposure and susceptibility, for example, immunocompromised status.

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Article Synopsis
  • * The report details a case of a 39-year-old woman who suffered from a seizure; her normal chest X-ray delayed the detection of MTB, ultimately leading to severe health consequences.
  • * It underscores the limitations of traditional chest X-rays in diagnosing MTB, recommending more advanced imaging techniques like chest CT or MRI, and stresses the importance of timely treatment, especially in developing countries affected by conflict and poverty.
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Refining the definition of miliary/disseminated tuberculosis in Canada.

Int J Infect Dis

November 2024

Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Electronic address:

Objectives: Although a "multisite" definition of disseminated tuberculosis (DTB) exists, there is limited evidence to support its use. Herein, we sought to generate that evidence.

Methods: We evaluated treatment outcomes and reporting requirements against two distinct definitions of DTB in a 15-year population-based cohort of consecutively diagnosed patients with tuberculosis (TB) in Canada.

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