EPH/EPHRIN signaling is crucial to the segregation of cell populations during the morphogenesis of many tissues. In this issue, Kindberg et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202005216) show that EPH activation can drive both heterotypic cell repulsion and homotypic aggregation by triggering increased cortical tension.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129807PMC
http://dx.doi.org/10.1083/jcb.202105015DOI Listing

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