Here we report the highly enantio- and -selective synthesis of β-hydroxy α-amino acids from glycine imine derivatives under Brønsted base (BB) catalysis. The key of this approach is the use of benzophenone-derived imine of glycine -nitroanilide as a pronucleophile, where the -nitroanilide framework provides an efficient hydrogen-bonding platform that accounts for nucleophile reactivity and diastereoselectivity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490875 | PMC |
| http://dx.doi.org/10.1021/acs.joc.1c00406 | DOI Listing |
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