AI Article Synopsis
- Bullous pemphigoid (BP) is an autoimmune skin disease linked to autoantibodies that primarily affects certain skin areas, with some cases manifesting locally after exposure to triggers.
- In a study of 285 BP patients, localized BP (LBP) was identified in 7 cases, where 5 remained localized while 2 spread after initial onset.
- The findings suggest LBP is rare, may be underdiagnosed, and should be included in differential diagnosis, especially when associated with potential triggering factors like infections.
Article Abstract
Bullous pemphigoid (BP) is an autoimmune skin disease, caused by autoantibodies to BP180 and/or BP230. While both these autoantigens are expressed in the entire skin, only some parts of the body become affected. Rare clinical observations indicate that BP may also manifest locally, usually following exposure to triggers. Here, we evaluated the occurrence and potential triggers of localized BP (LBP) in a cohort of 285 BP patients. Medical records of all BP patients hospitalized between 2009 and 2019 were reviewed. In 7/285 BP patients, a localized variant was identified. In 5/7 LBP patients, the disease remained local, while in 2/7 patients, an initial LBP subsequently spread. All cases were preceded by presumptive triggers, including previously described triggers and bacterial infections. Overall, LBP is rare. LBP, however, might be underdiagnosed and should thus be considered in the differential diagnosis, particularly when trigger factors preceded.
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| http://dx.doi.org/10.1111/1346-8138.15912 | DOI Listing |
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