AI Article Synopsis
- The fruit fly serves as a valuable genetic model for studying human neurodegenerative diseases, like Alzheimer's, helping researchers uncover disease mechanisms and potential treatments.
- A specific protocol is outlined for evaluating amyloid-β toxicity related to Alzheimer's in a transgenic fruit fly model, involving biochemical, histological, and behavioral assessments.
- The text also addresses the pros and cons of these research methods and directs readers to Wang et al. (2021) for detailed instructions.
Article Abstract
For decades, the fruit fly has been an efficient genetic model to investigate many aspects of human neurodegenerative diseases. Through genetic and pharmacologic approaches, these studies have revealed the molecular mechanisms underlying disease pathogenesis and provided therapeutic implications. Here, we describe a protocol for assessing Alzheimer's disease-related amyloid-β toxicity in a transgenic fly model through biochemical, histological, and behavioral analyses. We also discuss the advantages and limitations of our protocols. For complete details on the use and execution of this protocol, please refer to Wang et al. (2021).
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105684 | PMC |
| http://dx.doi.org/10.1016/j.xpro.2021.100501 | DOI Listing |
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