Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099597 | PMC |
http://dx.doi.org/10.1016/j.jdcr.2021.03.044 | DOI Listing |
Melanoma Res
December 2024
Department of Medicine, School of Medicine, University of Utah.
Acquired generalized lipodystrophy (AGL) is a rare complication of immune checkpoint inhibitors (ICIs) and is associated with immune-mediated loss of adipose tissue, peripheral resistance to insulin, and serious metabolic complications. Here we report a new case of ICI-induced AGL and provide an updated literature review of published cases. We report a 39-year-old female patient treated with adjuvant pembrolizumab for stage IIIC nevoid melanoma with ICI-induced AGL.
View Article and Find Full Text PDFPathology
September 2024
Department of Pathology, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, Valencia, Spain; Department of Pathology, University of Valencia Avenida Blasco Ibáñez, Spain. Electronic address:
Large nested melanomas (LNMs) are a rare subtype of naevoid melanoma consisting of large junctional melanocytic nests that are more common in older individuals and/or associated with sun damage. However, the presence of large melanocytic nests alone does not lead to a diagnosis of malignancy, as they can also be found in melanocytic naevi. LNMs are challenging because they lack most classic histological features of malignancy and require thorough clinicopathological evaluation.
View Article and Find Full Text PDFJ Surg Oncol
October 2024
Department of Surgical Oncology, Corewell Health, Grand Rapids, Michigan, USA.
Melanoma affects over one million people in the United States. This review explores genetic mutations and markers of all seven subtypes. Current treatment options and prognosis of each subtype are also discussed.
View Article and Find Full Text PDFAm J Dermatopathol
December 2024
Kossard Dermatopathologists, Laverty Pathology, Macquarie Park, NSW, Australia .
Background: In contrast to early-onset dysplastic nevi, late-onset atypical nevi of the elderly are more often precursors to distinctive nevoid melanomas. PReferentially expressed Antigen in MElanoma (PRAME) immunohistochemistry was applied to delineate the nevoid aspect of late-onset oncogenic nevoid pathway. Inducible Skin-Associated Lymphoid Tissue, regulatory T-cell mesenchymal hubs, has emerged as a translational tool and was used to define nevoid oncogenesis within a dynamic meta-analytic pathway.
View Article and Find Full Text PDFClin Exp Dermatol
October 2024
Department of Dermatology, Duke University School of Medicine, Durham, NC, USA.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!