AI Article Synopsis
- Breast cancer is the second most common cancer worldwide, with 2.09 million cases reported in 2018, and there’s a strong link between obesity and breast cancer risk.
- While obesity before menopause may reduce breast cancer risk, postmenopausal obesity increases it due to higher levels of estrogen produced by body fat.
- The review discusses how body fat contributes to estrogen production, the effects of estrogen exposure on fat distribution, and the mechanisms behind these processes.
Article Abstract
Breast cancer is the second highest prevalent cancer globally after lung cancer with 2.09 million cases during 2018. Adults about 1.9 billion were overweight and over 650 million out of these were obese during 2016. There is a significant relationship between breast cancer risk and obesity. Premature menopause and premenopausal obesity diminish the risk whereas postmenopausal obesity amplifies the risk, because adipose tissue acts as the major reservoir for estrogen biosynthesis after menopause. Lofty estrogen levels in serum along with enhanced peripheral site production of estrogen have been viewed as major reasons of developing breast cancer in overweight postmenopausal women. This review explains body fat as a peripheral site for estrogen biosynthesis, estrogen exposure affecting body fat distribution, and the mechanism of estrogen production from body fats.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099684 | PMC |
| http://dx.doi.org/10.1016/j.gendis.2019.09.006 | DOI Listing |
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