AI Article Synopsis
- Repulsive guidance molecule-a (RGMa) is a protein involved in the central nervous system's development and function, particularly in axon guidance and neural stem cell differentiation.
- RGMa interacts with its receptor Neogenin to regulate neural cell survival, but it also inhibits axonal growth, potentially hindering recovery from CNS injuries.
- Recent studies suggest RGMa's involvement in several CNS diseases, like multiple sclerosis and Parkinson's, indicating that targeting RGMa could improve treatment outcomes for these conditions.
Article Abstract
Repulsive guidance molecule-a (RGMa) is a member of glycosylphosphatidylinositol- (GPI-) anchored protein family, which has axon guidance function and is widely involved in the development and pathological processes of the central nervous system (CNS). On the one hand, the binding of RGMa and its receptor Neogenin can regulate axonal guidance, differentiation of neural stem cells into neurons, and the survival of these cells; on the other hand, RGMa can inhibit functional recovery of CNS by inhibiting axonal growth. A number of studies have shown that RGMa may be involved in the pathogenesis of CNS diseases, such as multiple sclerosis, neuromyelitis optica spectrum diseases, cerebral infarction, spinal cord injury, Parkinson's disease, and epilepsy. Targeting RGMa can enhance the functional recovery of CNS, so it may become a promising target for the treatment of CNS diseases. This article will comprehensively review the research progression of RGMa in various CNS diseases up to date.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112912 | PMC |
| http://dx.doi.org/10.1155/2021/5532116 | DOI Listing |
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