AI Article Synopsis
- A carbon nanotube (CNT) field-effect transistor (FET) biosensor was developed for the selective detection of SARS-CoV-2.
- The sensor was created using a flexible Kapton substrate and immobilized with a specific RNA sequence related to the virus.
- Testing showed the biosensor could specifically detect the virus with a sensitivity limit of 10 fM, indicating its potential as a diagnostic tool for COVID-19.
Article Abstract
In this work, we propose and demonstrate a carbon nanotube (CNT) field-effect transistor (FET) based biosensor for selective detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). CNT FETs were fabricated on a flexible Kapton substrate and the sensor was fabricated by immobilizing the reverse sequence of the RNA-dependent RNA polymerase gene of SARS-CoV-2 onto the CNT channel. The biosensors were tested for the synthetic positive and control target sequences. The biosensor showed a selective sensing response to the positive target sequence with a limit of detection of 10 fM. The promising results from our study suggest that the CNT FET based biosensors can be used as a diagnostic tool for the detection of SARS-CoV-2.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106884 | PMC |
| http://dx.doi.org/10.1016/j.matpr.2021.05.011 | DOI Listing |
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