The efficiency of the combined effect of 239Pu and tributyl phosphate was estimated by the severity of leucopenia in Wistar rats using the regression method and comparing the value of the actual change with the expected one. It was shown that the additive effect of the two agents delivered simultaneously was only exceeded when their doses were the largest that is, approximate the acute levels. With levels ranging from subacute effective to minimum effective ones the additivity diminished.
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It has been established in experiments on rats that under combined inhalation exposure to 239Pu along with TBP and HCLB in amounts which may cause the changes in blood and immune systems the enhancing of different non-stochastic effects on the average by two times on a basis of a unit absorbed dose in comparison with isolated nuclide inhalation.
View Article and Find Full Text PDF3.2-fold increase of resorption of plutonium-239 administered as a 239Pu complex with tributyl phosphate (TBP) in hexachlorobutadiene (HCBD) was observed during the first 4 days in an experiment on 120 Wistar rats, as compared to the resorption level during the administration of 239Pu alone, greater accumulation in the organs of secondary deposition, followed by disappearance of differences, but for the kidneys, where the differences were observed until the end of the experiment. These features did not lead to an increase of absorbed radiation doses in the critical organs by the end of the study.
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