Within the framework of an informational approach and the statistical method of comparison of qualitative parameters, a systemic factor is proposed, that is, the difference between entropy functions of hydrogen and carbon in the molecular structure that permits to reliably distinguish highly radioprotective agents among a series of drugs. A limiting factor (hydrophobicity) that restricts the manifestation of radioprotective properties of potential radioprotectors is considered. A relationship between toxic properties of the protective agents and their structure is discussed.
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