AI Article Synopsis
- Scrub typhus is caused by a trombiculid mite bite that infects humans, and pneumonia is commonly seen in affected patients.
- Researchers explored the effectiveness of intranasal vaccination with an outer membrane protein (OMPOT) to protect against this infection.
- The study found that this vaccination prompted strong immune responses and provided protective immunity against scrub typhus-related pneumonia in mice.
Article Abstract
Scrub typhus develops after the individual is bitten by a trombiculid mite infected with . Since it has been reported that pneumonia is frequently observed in patients with scrub typhus, we investigated whether intranasal (i.n.) vaccination with the outer membrane protein of (OMPOT) would induce a protective immunity against infection. It was particular interest that when mice were infected with , the bacteria disseminated into the lungs, causing pneumonia. The i.n. vaccination with OMPOT induced IgG responses in serum and bronchoalveolar lavage (BAL) fluid. The anti- IgA Abs in BAL fluid after the vaccination showed a high correlation of the protection against . The vaccination induced strong Ag-specific Th1 and Th17 responses in the both spleen and lungs. In conclusion, the current study demonstrated that i.n. vaccination with OMPOT elicited protective immunity against scrub typhus in mouse with infection causing subsequent pneumonia.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099613 | PMC |
| http://dx.doi.org/10.4110/in.2021.21.e14 | DOI Listing |
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