AI Article Synopsis
- The study aimed to evaluate how well amphotericin B (AMPH-B) penetrates the eyes after intravenous administration of liposomal amphotericin B (L-AMB) in patients with fungal eye infections.
- Seven eyes from five patients were treated with varying doses of L-AMB, and samples were taken from various eye fluids and blood to measure AMPH-B levels.
- Results showed high concentrations of AMPH-B in the cornea of the keratitis case, but much lower levels were found in the aqueous and vitreous humors, suggesting that L-AMB may only be effective for mild cases of fungal endophthalmitis.
Article Abstract
Purpose: To determine the intraocular penetration of amphotericin B (AMPH-B) after an intravenously injection of liposomal amphotericin B (L-AMB) in inflamed human eyes.
Methods: Seven eyes of 5 patients with fungal eye diseases (endophthalmitis in 6 eyes and keratitis in 1 eye) were treated with intravenous injections of 100-250 mg/day of L-AMB. Samples of blood, corneal button, aqueous humor, and vitreous humor were collected and assessed for AMPH-B.
Results: The AMPH-B level in the cornea (604.0 μg/g) of the case with fungal keratitis exceeded the minimum inhibitory concentration. However, the levels in the aqueous and vitreous humors of the cases with fungal endophthalmitis were lower, e.g., 0.02 ± 0.01 μg/ml (0.09% of serum level) in the aqueous humor and 0.05 ± 0.08 μg/ml (0.17% of serum level) in the vitreous humor.
Conclusions: The AMPH-B levels administered intravenously were very low in the aqueous and vitreous humors. Our findings indicate that intravenous L-AMB can be considered only for patients with mild endogenous fungal endophthalmitis, e.g., isolated chorioretinitis without vitreous extensions.
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| http://dx.doi.org/10.1016/j.jiac.2021.04.020 | DOI Listing |
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