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| http://dx.doi.org/10.1098/rstb.2020.0041 | DOI Listing |
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The value co-creation mechanism of Public Cultural Services ecosystem in China based on "public value" theory.
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Faculty of Humanities and Social Sciences, Macao Polytechnic University, Macao, Macao.
The establishment of China's public cultural service system has been explored for nearly two decades, but there is still a significant gap in achieving the goal of equalising and eliminating differences in public value, and it is urgent to systematically explore the public value governance issues contained in it. This paper presents a localised theoretical analysis framework based on the strategic triangle model of public value, with the objective of exploring the endogenous mechanism of China's public cultural services ecosystem (PCSE). Furthermore, it constructs a panel vector autoregression (PVAR) model from a dynamic endogenous perspective, employing the STATA 16.
View Article and Find Full Text PDFAddressing Unmet Needs in Eating Disorders Requires Systemic Change and Co-Production: A Commentary on Ali et al. (2024).
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The treatment gap for eating disorders varies significantly across healthcare systems owing to structural, cultural, and systemic barriers. A recent systematic review by Ali et al. highlighted this disparity, with treatment rates ranging from 2.
View Article and Find Full Text PDFGastric Cancer Models Developed via GelMA 3D Bioprinting Accurately Mimic Cancer Hallmarks, Tumor Microenvironment Features, and Drug Responses.
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Department of Surgical Oncology and General Surgery Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Current in vitro models for gastric cancer research, such as 2D cell cultures and organoid systems, often fail to replicate the complex extracellular matrix (ECM) found in vivo. For the first time, this study utilizes a gelatin methacryloyl (GelMA) hydrogel, a biomimetic ECM-like material, in 3D bioprinting to construct a physiologically relevant gastric cancer model. GelMA's tunable mechanical properties allow for the precise manipulation of cellular behavior within physiological ranges.
View Article and Find Full Text PDFLarge-scale production of infective larvae from engorged .
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Parasite and Vector Research Unit (PAVRU), Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.
Background: is transmitted by species and affects hundred millions of inhabitants in about 33 countries in sub-Saharan Africa. It is known that Mansonellosis due to do not result in a clear clinical picture, but down-regulates the immunity of patients predisposing them to other diseases like tuberculosis, HIV and malaria or damping vaccine efficacy. However, research about novel drugs against this filarial nematode is missing because of the lack of parasite material.
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Wolfson Sensory, Pain and Regeneration Centre, King's College London, London, United Kingdom.
Neuropathic pain following peripheral nerve injury results from maladaptive changes in neurons and immune cells contribution to mechanisms underlying chronic pain. Specifically, in dorsal root ganglia (DRG), sensory neuron cell bodies release extracellular vesicles (EVs) which promote pro-inflammatory macrophage accumulation that facilitates nociceptive signalling. Here, we show that macrophages shuttle EVs to neurons.
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