Construction of nanocarriers of different structures and properties have shown great promise as delivery systems for a wide range of drugs to improve therapeutic effects and reduce side effects. Nanostructured lipid carriers (NLCs) have been introduced as a new generation of solid lipid nanoparticles (SLNs) to overcome several of the limitations associated with the SLNs. NLCs consist of a blend of solid and liquid lipids which result in a partially crystallized lipid system that enables higher drug loading efficiency compared to SLNs. Owing to their biocompatibility, low toxicity, ease of preparation and scaling-up, and high stability, NLCs have been exploited in numerous pharmaceutical applications. Different methods for fabrication of NLCs have been described in the literature. In this article, procedures involved in emulsification-solvent evaporation method, one of the commonly utilized methods for preparation of NLCs, are described in detail. Critical aspects that should be considered throughout preparation process are also highlighted to allow for consistent and reproducible construction of NLCs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ymeth.2021.05.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Decoding Beta-Lactam Cross-Reactivity - Longitudinal Patch Testing From 2000 to 2022.
Contact Dermatitis
March 2025
Dermatology, University Hospital, Coimbra Local Health Unit, Coimbra, Portugal.
Introduction: Patients with non-immediate hypersensitivity to beta-lactam antibiotics (βL) often avoid all βL, with limitations for future therapy.
Objectives: Assess cross-reactivity between βL in non-immediate cutaneous adverse drug reactions (ni-CADRs).
Methods: Retrospective analysis (2000-2022) of patients with suspected ni-CADR with βL as a possible culprit who underwent patch testing (PT) with an extended antibiotic series (10% pet.
Two-Step Endodontic and Surgical Treatment of Large Periapical Lesions in the Maxilla: A Case Report.
Ann Ital Chir
March 2025
Department of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, 50-425 Wroclaw, Poland.
The aim of this article was to present a two-step procedure for treating two large periapical lesions located near the maxillary sinus. The first lesion measuring 7.1 mm by 6.
View Article and Find Full Text PDFMulti-cascade signal amplification and structure modulation strategy for highly sensitive and selective detection of cysteine using bovine serum albumin-stabilized gold nanoflowers as signal mediator.
Int J Biol Macromol
March 2025
College of Chemistry and Chemical Engineering, Henan Key Laboratory of Rare Earth Functional Materials, Zhoukou Normal University,Zhoukou, 466001, China.
A novel nanosensing system was constructed for highly sensitive and selective detection of cysteine (Cys) via the combination of the excellent optical properties of bovine serum albumin-stabilized gold nanoflowers (BSA-AuNFs), the high selectivity of the molecular structure regulation performance of cystine, and the high sensitivity of the multi-cascade signal amplification strategy. The sensing mechanism has been confirmed by UV-vis absorption spectroscopy, TEM, HRMS and H NMR spectra titration analysis, which can effectively improve the sensitivity and selectivity of the detection of Cys. In addition, the molecular structure regulation performance of cystine (disulfide bond effect) further improved the selectivity of this analytical system.
View Article and Find Full Text PDFSelf-powered temperature and humidity sensing platform based on AgS/poly(5-carboxyindole)/hydroxyethyl cellulose nanocomposite.
J Colloid Interface Sci
March 2025
Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China. Electronic address:
A self-powered dual-function temperature and humidity sensing platform is constructed based on AgS/poly(5-carboxyindole)/hydroxyethyl cellulose composite material (AgS/P5ICA/HEC). The AgS nanomaterial with reticular porous structure is successfully synthesized via a solvothermal method for use as electrodes in supercapacitors and temperature sensors. Then, a highly sensitive AgS/P5ICA/HEC-based humidity sensor is successfully prepared by drop-coating the surface of AgS material with P5ICA/HEC composite.
View Article and Find Full Text PDFDevelopment of an analytical platform that combines a lab-on-gel device with hydrogel layer-based deproteinization/sensing functions and a compact fluorescence imager.
Talanta
March 2025
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan. Electronic address:
An analytical platform was developed using agarose gel to overcome the issues of device miniaturization and interference effects caused by foreign proteins, which are challenges for field analysis-oriented measurement technology. The lab-on-gel (LoG) device integrates sample preparation, reaction, and detection on a chip, with an agarose gel for separation that preferentially allows only small molecules to pass through due to the size exclusion effect, and an agarose gel for sensing that contains glucose dehydrogenase and substrates. Measurements can be performed simply by dropping in a diluted serum sample and then placing the device in a custom-made compact Raspberry Pi-based fluorescence imager.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!