AI Article Synopsis
- A new class of H-PGDS inhibitors, specifically 2-phenylimidazo[1,2-a]pyridine-6-carboxamide, was discovered through a virtual screening process at GlaxoSmithKline.
- Detailed analysis of crystal structures and structure-activity relationships (SAR) resulted in the identification of a powerful, orally active imidazopyridine inhibitor, designated as 20b.
- The text discusses the identification of two types of inhibitors, their synthesis processes, and the challenges encountered during the research.
Article Abstract
Through an internal virtual screen at GlaxoSmithKline a distinct class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors were discovered. Careful evaluation of crystal structures and SAR led to a novel, potent, and orally active imidazopyridine inhibitor of H-PGDS, 20b. Herein, describes the identification of 2 classes of inhibitors, their syntheses, and their challenges.
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| http://dx.doi.org/10.1016/j.bmcl.2021.128113 | DOI Listing |
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