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Plasma Proteomic Markers of Iron and Risk of Diabetes in a Cohort of African American and White American Current and Former Smokers.
Diabetes Metab Syndr Obes
December 2024
Department of Medicine, National Jewish Health, Denver, CO, 80206, USA.
Background: Little information is available on iron with diabetes risk among African Americans, a population where both anemia and elevated ferritin are common. We tested whether plasma proteomic measurements of ferritin and transferrin were associated with increased diabetes risk in a cohort of current and former African American (NHB) and Non-Hispanic White (NHW) smokers.
Methods: NHB and NHW participants from the COPDGene study who were free of diabetes (n = 4693) at baseline were followed for incident diabetes.
Frequency and consequences of immune checkpoint inhibitor-associated inflammatory changes in different organs: an autopsy study over 13-years.
Mod Pathol
December 2024
Department of Pathology and Molecular Pathology, University Hospital of Zurich, Switzerland; University of Zurich, Switzerland.
While immune checkpoint inhibitors (ICIs) have revolutionized modern oncology, they are also associated with immune-related adverse events (irAEs). Previous histopathological descriptions of organ-related inflammatory changes do not consider systemic effects of ICIs, because of an absence of comprehensive autopsy studies. We performed a retrospective study on 42 whole-body autopsies of patients treated with ICIs from January 2011 to March 2024 to determine frequency, organ distribution and morphology of ICIs-associated inflammatory changes as well as their clinical relevance.
View Article and Find Full Text PDFIntroduction: Jaundice is a state of disease in liver function often along with gastrointestinal (GI) complications primarily characterized by hyperbilirubinemia. Other tests regarding liver function are often used besides bilirubin as during any liver complications biomarkers such as alanine aminotransferase (ALT), serum glutamic pyruvic transaminase (SGPT), aspartate aminotransferase (AST), serum glutamic-oxaloacetic transaminase (SGOT), alkaline phosphatase (ALP), and many other biomarkers even total protein metabolism might get disrupted and get released in the blood. However, no comparison or association among those biomarkers was determined in a cohort.
View Article and Find Full Text PDFMolecular, Histological, and Functional Changes in Acta1-MCM;FLExDUX4/+ Mice.
Int J Mol Sci
October 2024
NIHR Biomedical Research Centre, University College London, Great Ormond Street Institute of Child Health and Great Ormond Street Hospital NHS Trust, London WC1N 1EH, UK.
Article Synopsis
An observational study of the causes of an isolated elevated alkaline phosphatase level of unclear etiology.
Am J Med Sci
October 2024
Digestive Disease Research Center, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 908, Charleston, SC 29425, USA. Electronic address:
Article Synopsis
- Serum alkaline phosphatase (ALP) is frequently tested in patients, but it lacks specific diagnostic value since it can originate from multiple tissues; this study explores causes of isolated elevated ALP levels without a clear reason.
- A retrospective study at the Medical University of South Carolina looked at 260 adults with unexplained elevated ALP results and found that 57% of cases were linked to underlying malignancies, particularly related to the liver and bones.
- The study highlights the importance of recognizing an isolated elevated ALP as potentially indicative of serious conditions, especially metastatic cancer, rather than just primary liver issues.
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