AI Article Synopsis
- The study explores how the nitrogen and sulfur atoms in the -NH-SO group of thiazine sulfonamides interact with each other.
- Researchers discovered that these compounds can form different diastereomers based on the configuration of the nitrogen atom, affecting the overall structure of the sulfur atom.
- The paper introduces a new stereochemical process termed "double crystallization-induced diastereomerization," highlighting a transformation that occurs during crystallization.
Article Abstract
The interrelation between the configurational lability of nitrogen and sulfur atoms within the -NH-SO group of some thiazine sulfonamides is discussed. We have found that the compounds of the above series can crystallize as various diastereomers by the nitrogen atom, the relative configuration of the nitrogen atom determining the relative supramolecular configuration of the newly formed chiral sulfur atom. The paper presents a stereochemical transformation, which we have called "double crystallization-induced diastereomerization."
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| http://dx.doi.org/10.1002/chir.23316 | DOI Listing |
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