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Function: insertAPISummary
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Diabetic neuropathy is an incurable disease. We previously identified a mechanism by which aberrant bone marrow-derived cells (BMDCs) pathologically expressing proinsulin/TNF-α fuse with residential neurons to impair neuronal function. Here, we show that CD106-positive cells represent a significant fraction of short-term hematopoietic stem cells (ST-HSCs) that contribute to the development of diabetic neuropathy in mice. The important role for these cells is supported by the fact that transplantation of either whole HSCs or CD106-positive ST-HSCs from diabetic mice to non-diabetic mice produces diabetic neuronal dysfunction in the recipient mice via cell fusion. Furthermore, we show that transient episodic hyperglycemia produced by glucose injections leads to abnormal fusion of pathological ST-HSCs with residential neurons, reproducing neuropathy in nondiabetic mice. In conclusion, we have identified hyperglycemia-induced aberrant CD106-positive ST-HSCs underlie the development of diabetic neuropathy. Aberrant CD106-positive ST-HSCs constitute a novel therapeutic target for the treatment of diabetic neuropathy.
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http://dx.doi.org/10.1038/s42003-021-02082-5 | DOI Listing |
BMJ Open Diabetes Res Care
December 2024
Deparment of Medicine, Division of Infectious Diseases, Emory University, Atlanta, Georgia, USA
Introduction: There are limited data regarding the associations between public transportation reliance, availability, and diabetic foot ulcer (DFU)-related amputations.
Research Design And Methods: We used visit-level data from the Georgia 2016-2019 Healthcare Cost and Utilization Project database and obtained transportation variables from open sources. Using Bayesian spatial-temporal models, we assessed the associations between transportation and DFU-related amputations within each quartile of poverty status indicators at the ZIP code tabulation area (ZCTA) level.
J Med Case Rep
December 2024
Beijing Acupuncture and Chinese Herbology, 19 Edgemoor Road, Lutherville-Timonium, MD, 21093, USA.
Background: Magnetic therapy has demonstrated beneficial effects for reducing pain, nausea, neuropathy, and various other health concerns in the human body. To our knowledge, limited research has documented the use of auricular static magnetic therapy as a potential treatment for diabetes. This report presents the first evidence of using magnetic discs placed at acupuncture points on the human ear to decrease blood glucose levels and promote the healing of gangrene in diabetic patients.
View Article and Find Full Text PDFCureus
November 2024
Institute of Ophthalmology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University (AMU), Aligarh, IND.
Background: Diabetes mellitus (DM) is a global disease that is strongly associated with both microvascular and macrovascular complications. A significant proportion of individuals with diabetes develop diabetic retinopathy (DR), a microvascular complication that can lead to blindness, particularly in working-age adults. Diabetes adversely affects the entire neurosensory retina, with accelerated neuronal apoptosis and activation or altered metabolism of neuroretinal supporting cells.
View Article and Find Full Text PDFDiabetes Metab Syndr Obes
December 2024
Department of Endocrinology, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui, People's Republic of China.
Objective: Studies have demonstrated a link between chronic inflammatory responses and diabetic microangiopathy, which include diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy. However, it remains unclear whether there is a causal association between circulating inflammatory cytokines and the development of diabetic microvascular complications. This study aimed to investigate whether altered genetically predicted concentrations of circulating inflammatory cytokines were associated with the development of diabetic microvascular complications using two-sample Mendelian randomization (MR) analysis and clinical validation.
View Article and Find Full Text PDFRev Bras Ortop (Sao Paulo)
December 2024
Departamento de Ortopedia e Anestesiologia, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
This study presents a retrospective study of persistent median artery associated with carpal tunnel syndrome (CTS). A retrospective study of the persistent median artery and CTS. Exclusion criteria were patients who did not present persistent median artery, those who were diabetic, or had rheumatoid diseases, and those who decided not to do the surgery.
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