AI Article Synopsis
- Tourette syndrome (TS) is a neurobehavioral disorder with unclear neurological mechanisms, and previous studies on gray matter volume (GMV) in TS patients have shown inconsistent results.
- A voxel-wise meta-analysis using seed-based d mapping (SDM) was conducted, analyzing ten relevant studies to assess regional gray matter abnormalities in TS patients compared to healthy controls.
- The findings revealed that TS patients exhibited reduced GMV in the inferior frontal gyri but increased GMV in the cerebellum, right striatum, and thalamus, confirming significant changes in the cortico-striato-thalamo-cortical network, with no correlations found between GMV alterations and demographic or clinical factors.
Article Abstract
Tourette syndrome (TS) is a neurobehavioral disorder for which the neurological mechanism has not been elucidated. Voxel-based morphometry (VBM) studies have revealed abnormalities in gray matter volume (GMV) in patients with TS; however, consistent results have not been obtained. The current study attempted to provide a voxel wise meta-analysis of gray matter changes using seed-based d mapping (SDM). We identified ten relevant studies that investigated gray matter alterations in TS patients and performed a meta-analysis using the SDM method to quantitatively estimate regional gray matter abnormalities. Next, we examined the relationships between GMV abnormalities and demographic and clinical characteristics. Our results demonstrated that TS patients had smaller GMV in the bilateral inferior frontal gyri and greater GMV in the cerebellum, right striatum (putamen), and bilateral thalami (pulvinar nucleus) than healthy controls. A meta-regression analysis did not identify correlations between GMV changes and demographic or clinical variables. This meta-analysis confirmed significant and consistent GMV changes in several brain regions of TS patients, primarily in the cortico-striato-thalamo-cortical network.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121885 | PMC |
| http://dx.doi.org/10.1038/s41398-021-01394-8 | DOI Listing |
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