AI Article Synopsis
- - Recurrent tonsillitis is primarily caused by bacteria like Streptococcus pyogenes and Haemophilus influenzae, prompting research on effective antibacterial treatments.
- - The study tested five antibiotics on Detroit 562 cells invaded by multiple strains of these bacteria, revealing various levels of effectiveness.
- - Garenoxacin was found to be the most effective antibiotic against the intracellular invasion of both NTHi and S. pyogenes, while amoxicillin and cefditoren pivoxil showed no effectiveness.
Article Abstract
Background: Recurrent tonsillitis is one of the most common otolaryngological disorders caused by cell-invading bacteria, such as Streptococcus pyogenes (S. pyogenes) and Haemophilus influenzae. The aim of this study was to investigate the effect of antibacterial agents against cell-invading bacteria.
Methods: The intracellular invasion of Detroit 562 cells by five strains of nontypeable Haemophilus influenzae (NTHi) and four strains of S. pyogenes was investigated. The antibacterial agents used were garenoxacin (GRNX), clarithromycin (CAM), amoxicillin (AMPC), cefditoren pivoxil (CDTR-PI), and levofloxacin (LVFX).
Results: Both NTHi and S. pyogenes fully invaded Detroit 562 cells in 6 h and were less sensitive to CAM. GRNX, CAM, and LVFX were effective against bacteria invading the cells, but AMPC and CDTR-PI were not effective. GRNX was the most effective.
Conclusion: GRNX was the most effective agent against bacteria invading cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122569 | PMC |
| http://dx.doi.org/10.1186/s12866-021-02217-y | DOI Listing |
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