Background: Burns are a global public health concern, with the majority of the disease burden affecting low- and middle-income countries. Yet, as suggested by previous publications, there is a widespread belief that literature about burns in low- and middle-income countries is lacking. Therefore, we aimed to assess with a scoping review, the extent of the literature output on burns in East Africa, and to investigate patient demographics, injury characteristics, treatment and outcomes, as reported from the existing publications.
Methods: Studies discussing burns in East Africa were identified by searching PubMed / Medline (National Library of Medicine), EMBASE (Elsevier), Global Health Database (EBSCO), and Global Index Medicus on December 12, 2019. Controlled vocabulary terms (i.e., MeSH, EMTREE, Global Health thesaurus terms) were included when available and appropriate. No year restrictions were applied.
Results: A total of 1,044 records were retrieved from the database searches, from which 40 articles from 6 countries published between 1993 and 2019 were included in the final review. No studies were found from five East African countries with the lowest GDP. Most papers focused on pediatric trauma patients or tertiary hospital settings. The total number of burn patients recorded was 44,369, of which the mean proportion of males was 56%. The most common cause of injury was scalds (61%), followed by open flame (17%). Mortality rate ranged from 0-67%. The mean length of stay in hospital was between 9-60 d.
Conclusions: Burn data is limited in the East African region, with socio-economically weak countries being particularly underrepresented. This scoping review has identified the largest set of literature on burns in East Africa to date, indicating the importance of reviewing data at a regional or local level, as "global" studies tend to be dominated by high-income country data. Data collection in specific registries is needed to better characterize the exact burden of burn injuries in East Africa.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.jss.2021.03.055 | DOI Listing |
Environ Sci Technol
December 2024
Climate and Environmental Physics, Physics Institute, and Oeschger Centre for Climate Change Research, University of Bern, Sidlerstrasse 5, Bern 3012, Switzerland.
This study presents the integration of the single-particle extinction and scattering (SPES) method in a continuous flow analysis (CFA) setup. Continuous measurements with the instrument allow for the characterization of water-insoluble particles in ice cores at high resolution with a minimized risk of contamination. The SPES method can be used to investigate particles smaller than 1 μm, which previously could not be detected by instruments typically used in CFA.
View Article and Find Full Text PDFMar Pollut Bull
December 2024
School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
Mercury (Hg) is a global pollutant of widespread concern, and modern Hg levels have been much elevated compared to pre-industrial levels. The majority of environmental Hg assessment has occurred in the developed world within the temperate region, but recent years we have witnessed increases in research activities in polar, subtropical, and tropical biomes. East Asia is currently the biggest emitter of anthropogenic Hg, while intense research is ongoing in China, Korea, and Japan, relatively little has been done in the neighboring regions.
View Article and Find Full Text PDFBMC Surg
December 2024
Department of Research and Education, Oli Health Magazine Organization, Research and Education, Kigali, Rwanda.
Introduction: Plastic surgery is an essential yet underdeveloped field in many African nations, especially in rural areas. The demand for plastic surgery is increasing, but differences in access to respective services between rural and urban domiciles remain ever existent, despite the exponentiation of trauma, burns, and congenital disorders. According to this review, urban areas have access to better facilities and specialized surgeons, while rural areas frequently lack infrastructure, educated healthcare personnel, and medical resources.
View Article and Find Full Text PDFJ Inflamm Res
December 2024
Department of Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
Purpose: Severe burns result in significant skin damage, impairing its primary role as an infection barrier and presenting substantial treatment challenges. Despite improvements in the treatment of burn patients due to advancements in materials and techniques, there remains a need for novel therapeutic approaches to enhance burn prognosis further.
Patients And Methods: Several types of genomic methods are used in this study, such as differential gene expression analysis, weighted gene co-expression network analysis (WGCNA), machine learning, and Mendelian randomization (MR), to find genes that are linked to severe burns and create a diagnostic nomogram to see how well these genes can predict severe burns.
Signal Transduct Target Ther
December 2024
State Key Laboratory of Molecular Oncology, CAMS Key Laboratory of Translational Research on Lung Cancer, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
A randomized double-blind phase 3 trial (CHOICE-01, NCT03856411) demonstrated that combining toripalimab with chemotherapy substantially improves progression-free survival (PFS) in advanced non-small cell lung cancer (NSCLC) patients without pretreatment. This study presents the prespecified final analysis of overall survival (OS) and biomarkers utilizing circulating tumor DNA (ctDNA) and tissue-based sequencing. Additionally, the analysis revealed a higher median overall survival (OS, 23.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!