Parathyroid hormone (PTH), which is primarily regulated by extracellular calcium changes, controls calcium and phosphate homeostasis. Different diseases are derived from PTH deficiency (hypoparathyroidism), excess (hyperparathyroidism) and resistance (pseudohypoparathyroidism, PHP). Pseudohypoparathyroidism was historically classified into subtypes according to the presence or not of inherited PTH resistance associated or not with features of Albright's hereditary osteodystrophy and deep and progressive ectopic ossifications. The growing knowledge on the PTH/PTHrP signaling pathway showed that molecular defects affecting different members of this pathway determined distinct, yet clinically related disorders, leading to the proposal of a new nomenclature and classification encompassing all disorders, collectively termed inactivating PTH/PTHrP signaling disorders (iPPSD).
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http://dx.doi.org/10.1016/j.mce.2021.111311 | DOI Listing |
Introduction: Pseudohypoparathyroidism 1A (PHP1A) is the best-known representative of inactivating PTH/PTHrP signaling disorders (iPPSD). The associated phenotype develops over time and often includes hormonal resistances, short stature and osteoma cutis. More complex and very early manifestations have also been reported.
View Article and Find Full Text PDFJ Orthop Surg Res
January 2025
Medical Physiology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Background: Castration of adult male rats led to the development of osteoporosis. Oxidative stress and inflammatory factors have been identified as potential causative factors. Notably, oxymatrine (OMT) possesses potent anti-inflammatory and antioxidant activities.
View Article and Find Full Text PDFJ Diabetes Metab Disord
June 2025
Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.
Background: Middle Eastern (ME) immigrants to Europe have a heavy burden of metabolic disorders including a higher prevalence of insulin resistance, T2D and obesity as compared to native-born Europeans. Vitamin D insufficiency and deficiency are prevalent conditions in people originating from the ME.
Aims: To study the differences in the levels of 25(OH)D and parathyroid hormone (PTH) across ME and European ethnicity, and the effect of 25(OH)D and PTH on insulin action and secretion.
Nanotechnology
December 2024
Chemistry and Biochemistry, North Carolina Central University, North Carolina Central University USA, Durham, 27707-3129, UNITED STATES.
Ciprofloxacin (CIP) is a widely used antibiotic, and its presence in water bodies poses a risk due to its resistance to conventional wastewater treatment processes. The accumulation of such pharmaceuticals can disrupt aquatic ecosystems, harm aquatic life, and contribute to ecological imbalances. Therefore, the degradation of CIP is of immense environmental significance.
View Article and Find Full Text PDFJ Bone Metab
November 2024
Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Chronic kidney disease (CKD) often leads to mineral and bone disorders (CKD-MBDs), which are nearly universal in patients undergoing dialysis. CKD-MBD includes abnormal calcium-phosphate metabolism, vascular and soft tissue calcification, and bone abnormalities (renal osteodystrophy [ROD]). Bone fragility in CKD occurs due to low bone mass and poor bone quality, and patients with CKD have higher fracture and mortality rates.
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