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Epidermal growth factor receptor-mutated lung carcinomas with insufficient response to epidermal growth factor receptor inhibitors.
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N.N. Petrov National Medical Research Center of Oncology, Ministry of Public Health of the Russian Federation, Saint-Petersburg, Russia.
Administration of single-agent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is a standard treatment option for metastatic non-small cell lung carcinomas with EGFR exon 19 deletions (ex19del) and L858R substitutions. However, there is a significant interpatient heterogeneity with regard to the degree of the response and its duration. Patients with EGFR ex19del mutation, TP53 wild-type, good performance status, low tumor burden and no circulating tumor DNA (ctDNA) at baseline have the best chances to derive pronounced benefit from TKI therapy.
View Article and Find Full Text PDFImmunogenic properties of SARS-CoV-2 inactivated by ultraviolet light.
Arch Virol
November 2022
I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, 105064, Russia.
Vaccination against COVID-19 is the most effective method of controlling the spread of SARS-CoV-2 and reducing mortality from this disease. The development of vaccines with high protective activity against a wide range of SARS-CoV-2 antigenic variants remains relevant. In this regard, evaluation of the effectiveness of physical methods of virus inactivation, such as ultraviolet irradiation (UV) of the virus stock, remains relevant.
View Article and Find Full Text PDFIn Regard to Moiseenko et al.
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Department of Radiation Oncology, City of Hope National Medical Center, Duarte, California.
[Opportunistic bacteria in the seawater of recreational areas].
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In the coastal water of several seas lying in different climatic zones the content of such opportunistic bacteria as Klebsiella and Pseudomonas aeruginosa was determined. Correlative relationships between Klebsiella, P. aeruginosa, lactose-positive Escherichia coli, fecal E.
View Article and Find Full Text PDFProblems of coastal waters sanitary and bacteriologic inspection are discussed. Lactose positive E. coli and Enterococcus indexes as key, and Pseudomonas aeruginosa index as a supplementary one are suggested.
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