AI Article Synopsis
- A new method for regioselective radical C-H trifluoromethylation of aromatic compounds uses cyclodextrins (CDs) as additives.
- This process shows high regioselectivity and yields the desired products effectively, even in larger quantities (gram scale).
- H NMR studies suggest that the regioselectivity is influenced by the ability of substrates to fit inside the CD cavity, leading to selective reactions.
Article Abstract
A regioselective radical C-H trifluoromethylation of aromatic compounds was developed using cyclodextrins (CDs) as additives. The C-H trifluoromethylation proceeded with high regioselectivity to afford the product in good yield, even on the gram scale. In the presence of CDs, some substrates underwent a single trifluoromethylation selectively, whereas mixtures of single- and double-trifluoromethylated products were formed in the absence of the CD. H NMR experiments indicated that the regioselectivity was controlled by the inclusion of a substrate inside the CD cavity.
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| http://dx.doi.org/10.1021/acs.orglett.1c01259 | DOI Listing |
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