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Dual-Engineered Phage Vaccine Platform Facilitates STING Activation for Influenza Protection.
ACS Appl Mater Interfaces
January 2025
Department of Cardiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362400, China.
Influenza epidemics remain a global public health challenge. Vaccination with nucleic acid-based vaccines, which trigger strong cellular and humoral immune responses, represents a promising approach for preventing virus infection. However, its effectiveness relies on efficient delivery and an immunoadjuvant.
View Article and Find Full Text PDFEngineering Nanoclusters of Cell Adhesive Ligands on Biomaterial Surfaces: Superior Cell Proliferation and Myotube Formation for Skeletal Muscle Tissue Regeneration.
Adv Healthc Mater
January 2025
Department of Biomedical Engineering, Graeme Clark Institute, University of Melbourne, Parkville, 3010, Australia.
Engineering biointerfaces with nanoscale clustering of integrin-binding cell adhesive peptides is critical for promoting receptor redistribution into signaling complexes. Skeletal muscle cells are exquisitely sensitive to integrin-mediated signaling, yet biomaterials supporting myogenesis through control of the density and nanodistribution of ligands have not been developed. Here, materials are developed with tailorable cell adhesive ligands distribution at the interface by independently controlling their global and local density to enhance myogenesis, by promoting myoblast growth and myotube formation.
View Article and Find Full Text PDFDNA microbeads for spatio-temporally controlled morphogen release within organoids.
Nat Nanotechnol
December 2024
Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg University, Heidelberg, Germany.
Organoids are transformative in vitro model systems that mimic features of the corresponding tissue in vivo. However, across tissue types and species, organoids still often fail to reach full maturity and function because biochemical cues cannot be provided from within the organoid to guide their development. Here we introduce nanoengineered DNA microbeads with tissue mimetic tunable stiffness for implementing spatio-temporally controlled morphogen gradients inside of organoids at any point in their development.
View Article and Find Full Text PDFTurning foes to friends: Advanced " nanovaccine" with dual immunoregulation for enhanced immunotherapy of metastatic triple-negative breast cancer.
Bioact Mater
September 2024
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, PR China.
As a "cold tumor", triple-negative breast cancer (TNBC) exhibits limited responsiveness to current immunotherapy. How to enhance the immunogenicity and reverse the immunosuppressive microenvironment of TNBC remain a formidable challenge. Herein, an " nanovaccine" Au/CuNDs-R848 was designed for imaging-guided photothermal therapy (PTT)/chemodynamic therapy (CDT) synergistic therapy to trigger dual immunoregulatory effects on TNBC.
View Article and Find Full Text PDFA library of reporters of the global regulators of gene expression in .
mSystems
June 2024
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
The topology of the transcription factor network (TFN) of is far from uniform, with 22 global regulator (GR) proteins controlling one-third of all genes. So far, their production rates cannot be tracked by comparable fluorescent proteins. We developed a library of fluorescent reporters for 16 GRs for this purpose.
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