A Novel Antigen, Otubain Cysteine Peptidase of Leishmania donovani, for the Serodiagnosis of Visceral Leishmaniasis and for Monitoring Treatment Response.

Mohd Kamran Sarfaraz Ahmad Ejazi Somsubhra Thakur Choudhury Anirban Bhattacharyya Km Tanishka Krishna Pandey Vidya Nand Ravi Das Pradeep Das Fernando Oliveira da Silva Dorcas Lamounier Costa Carlos Henrique Nery Costa Mehebubar Rahaman Rama Prosad Goswami Nahid Ali

Clin Infect Dis

Infectious Diseases and Immunology Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.

Published: October 2021

Tests for visceral leishmaniasis (VL) are not uniformly effective for all endemic regions. In a serological assay, a novel antigen, otubain cysteine peptidase, compared with rK39, showed comparable sensitivity with Indian VL serum samples and prominently increased sensitivity with Brazilian samples, as well as improved monitoring of the treatment response.

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http://dx.doi.org/10.1093/cid/ciab435	DOI Listing

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