AI Article Synopsis
- Ischemic stroke is a major cause of disability and often leads to cognitive problems in survivors.
- Researchers investigated the effects of Shexiang Baoxin Pill (SBP), a Chinese medicine, on brain cells and a rat model of post-stroke cognitive impairment.
- Findings showed that SBP improved cell survival and cognitive functions by activating specific signaling pathways and regulating protein expressions, suggesting it could be a promising treatment for post-stroke cognitive issues.
Article Abstract
Ischemic stroke is a common type of cerebrovascular event and also the leading cause of disability. Post-stroke cognitive impairment occurs frequently in stroke survivors. Shexiang Baoxin Pill (SBP) is a proprietary Chinese medicine, initially used to treat cardiovascular diseases. Herein, we aim to explore the effects of SBP on oxygen glucose deprivation and reoxygenation (OGD/R) in neuronal cells (CATH.a) and cerebral ischemia/reperfusion injury induced post-stroke cognitive impairment in middle cerebral artery occlusion (MCAO) rat model. MCAO rats received two doses of oral SBP treatment (28 or 56 mg/kg) after 1 h of operation and once daily for 2 weeks continuously. Behavioral tests, immunoblotting, and immunofluorescence were examined after 14 days. Current data suggest that SBP enhanced cell viability and downregulated apoptosis via activating the PI3K/Akt signaling pathway in CATH. a cells. Furthermore, 14 days of SBP treatment promoted the recovery of learning and locomotor function in the MCAO rats. SBP up-regulated the expression of p-Akt, p-GSK3β, as well as the expression of NMDAR1, PSD-95, and AMPAR. Also, SBP down-regulated the expression of p-CaMKII. These results indicated that long-term SBP treatment might be a potential option for cognitive impairment induced by the ischemic stroke.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111446 | PMC |
| http://dx.doi.org/10.3389/fphar.2021.665456 | DOI Listing |
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