AI Article Synopsis
- A study on the ethanol extract of Pojark roots identified 20 compounds, including two new ones called kompasinol P and a specific isoflavanone.
- Enantiomers of kompasinol A were separated using chiral-phase HPLC for the first time, with their configurations determined through electronic circular dichroism data.
- Fifteen isolated compounds were tested for their anti-inflammatory properties, showing moderate inhibition of nitric oxide production in stimulated macrophage cells with IC values between 11.45 and 68.54 μM.
Article Abstract
A phytochemical investigation on the 80% ethanol extract of the roots of Pojark. resulted in the isolation of 20 compounds, including two new ones, named kompasinol P () and 3,5,7,2',3'-pentahydroxy-4'-methoxyisoflavanone (). Among them, a pair of enantiomers, (7, 8 , 7', 8')kompasinol A ( and (7 , 8, 7', 8')-kompasinol A (), were successfully separated by the chiral-phase HPLC resolution for the first time. The absolute configurations of and were determined by the experimental and calculated electronic circular dichroism (ECD) data. 15 isolates were evaluated for their anti-inflammatory activity inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells. Compounds , , , , , , , and - showed moderate inhibition with IC values ranging from 11.45 to 68.54 μM.
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| http://dx.doi.org/10.1080/10286020.2021.1918119 | DOI Listing |
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Article Synopsis
- A study on the ethanol extract of Pojark roots identified 20 compounds, including two new ones called kompasinol P and a specific isoflavanone.
- Enantiomers of kompasinol A were separated using chiral-phase HPLC for the first time, with their configurations determined through electronic circular dichroism data.
- Fifteen isolated compounds were tested for their anti-inflammatory properties, showing moderate inhibition of nitric oxide production in stimulated macrophage cells with IC values between 11.45 and 68.54 μM.
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