A 980 nm semiconductor laser is always selected as the pump source for erbium-ytterbium co-doped optical waveguide amplifiers. In this work, two low-cost blue-violet LEDs, rather than an expensive 980 nm laser, were used to pump an Er-Yb co-doped phosphate planar waveguide. When the signal power was 0.4 mW at a 1550 nm wavelength, internal optical gains of about 4.1 and 4.5 dB/cm were respectively obtained under the excitations of a 32 mW/cm, 275 nm LED and a 914 mW/cm, 405 nm LED. It was found that 51.17% of the total Er ions in the H state contributed to the luminescence at 1550 nm, and a theoretical model of gain simulation was established under the excitation of a 405 nm LED. The calculated gain of about 4.1 dB/cm was found to be in accordance with the experimental optical gain results.
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http://dx.doi.org/10.1364/OE.414847 | DOI Listing |
Clin Ther
January 2025
Acadia Pharmaceuticals, Inc., San Diego, California. Electronic address:
Purpose: Rett syndrome (RTT) is a rare neurodevelopmental disorder that mainly affects girls and women. Trofinetide is approved for the treatment of RTT in adults and children aged ≥2 years. To gain insight into experiences with RTT and effects of trofinetide treatment at different stages of RTT, interviews with caregivers of individuals with RTT were conducted upon their exit from the open-label trofinetide trials.
View Article and Find Full Text PDFNeurol Neuroimmunol Neuroinflamm
March 2025
Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney.
Background And Objectives: Despite the absence of acute lesion activity in multiple sclerosis (MS), chronic neurodegeneration continues to progress, and a potential underlying mechanism could be the kynurenine pathway (KP). Prolonged activation of the KP from chronic inflammation is known to exacerbate the progression of neurodegenerative diseases through the production of neurotoxic metabolites. Among the 8 KP metabolites, six of them, namely kynurenine (KYN), 3-hydroxylkynurenine (3HK), anthranilic acid (AA), kynurenic acid (KYNA), and quinolinic acid (QUIN), have been associated with neurodegeneration.
View Article and Find Full Text PDFAm J Ophthalmol Case Rep
December 2024
California Pacific Medical Center Department of Ophthalmology, 711 Van Ness, Suite 250, San Francisco, CA, 94102, USA.
Purpose: To report the case of a woman in her fifties whose presenting symptom of idiopathic intracranial hypertension was engorgement of the eyelid veins.
Observations: Bilateral engorged palpebral veins were visible through the skin. Dilated fundus examination revealed bilateral optic disc edema.
Nat Commun
January 2025
Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO, USA.
Myelin loss induces neural dysfunction and contributes to the pathophysiology of neurodegenerative diseases, injury conditions, and aging. Because remyelination is often incomplete, better understanding endogenous remyelination and developing remyelination therapies that restore neural function are clinical imperatives. Here, we use in vivo two-photon microscopy and electrophysiology to study the dynamics of endogenous and therapeutic-induced cortical remyelination and functional recovery after cuprizone-mediated demyelination in mice.
View Article and Find Full Text PDFCell Rep
January 2025
Department of Medical Neuroscience, Dalhousie University, Halifax, NS B3H 4R2, Canada. Electronic address:
While considerable progress has been made in understanding the neuronal circuits that underlie the patterning of locomotor behaviors, less is known about the circuits that amplify motoneuron output to adjust muscle force. Here, we demonstrate that propriospinal V3 neurons (Sim1) account for ∼20% of excitatory input to motoneurons across hindlimb muscles. V3 neurons also form extensive connections among themselves and with other excitatory premotor neurons, such as V2a neurons.
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