AI Article Synopsis
- - The study examines the anti-prion effects of cellulose ether (CE) in rodents, focusing on understanding its effectiveness at a molecular level.
- - Researchers conducted proteomic and genetic analysis on different mouse lines to identify genetic factors associated with CE effectiveness, finding notable differences linked to the glia maturation factor β gene.
- - Several genetic polymorphisms related to CE effectiveness were discovered, providing potential markers for further research on prion resistance in mice.
Article Abstract
Anti-prion effects of cellulose ether (CE) are reported in rodents, but the molecular mechanism is fully unknown. Here, we investigated the genetic background of CE effectiveness by proteomic and genetic analysis in mice. Proteomic analysis in the two mouse lines showing a dramatic difference in CE effectiveness revealed a distinct polymorphism in the glia maturation factor β gene. This polymorphism was significantly associated with the CE effectiveness in various prion-infected mouse lines. Sequencing of this gene and its vicinity genes also revealed several other polymorphisms that were significantly related to the CE effectiveness. These polymorphisms are useful as genetic markers for finding more suitable mouse lines and exploring the genetic factors of CE effectiveness.
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| http://dx.doi.org/10.1016/j.bbrc.2021.04.116 | DOI Listing |
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