Serum protein adsorption on the nanoparticle surface determines the biological identity of polymeric nanocarriers and critically impacts the stability following intravenous injection. Ultrahydrophilic surfaces are desired in delivery systems to reduce the serum protein corona formation, prolong drug pharmacokinetics, and improve the performance of nanotherapeutics. Zwitterionic polymers have been explored as alternative stealth materials for biomedical applications. In this study, we employed facial solid-phase peptide chemistry (SPPC) to synthesize multifunctional zwitterionic amphiphiles for application as a drug delivery vehicle. SPPC facilitates synthesis and purification of the well-defined dendritic amphiphiles, yielding high-purity and precise architecture. Zwitterionic glycerylphosphorylcholine (GPC) was selected as a surface moiety for the construction of a ultrahydrophilic dendron, which was coupled on solid phase to a hydrophobic dendron using multiple rhein (Rh) molecules as drug-binding moieties (DBMs) for doxorubicin (DOX) loading pi-pi stacking and hydrogen bonding. The resulting zwitterionic amphiphilic Janus dendrimer (denoted as GPC-Rh) showed improved stabilities and sustained drug release compared to the analogue with poly(ethylene glycol) (PEG) surface (PEG-Rh). studies in xenograft mouse tumor models demonstrated that the DOX-GPC-Rh nanoformulation significantly improved anticancer effects compared to DOX-PEG-Rh, owing to the improved pharmacokinetics and increased tumor accumulation.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.molpharmaceut.1c00163DOI Listing

Publication Analysis

Top Keywords

facial solid-phase
8
zwitterionic amphiphiles
8
drug delivery
8
serum protein
8
zwitterionic
5
solid-phase synthesis
4
synthesis well-defined
4
well-defined zwitterionic
4
amphiphiles enhanced
4
enhanced anticancer
4

Similar Publications

We proposed and investigated a refinement of technology for obtaining Mg-doped LiNbO (LN) crystals by co-doping it with B. LN:Mg (5.0 mol%) is now the most widely used material based on bulk lithium niobate.

View Article and Find Full Text PDF

The clinical diagnosis of dermatophytosis and identification of dermatophytes face challenges due to reliance on culture-based methods. Rapid, cost-effective detection techniques for volatile organic compounds (VOCs) have been developed for other microorganisms, but their application to dermatophytes is limited. This study explores using VOCs as diagnostic markers for dermatophytes.

View Article and Find Full Text PDF

Organ shortage remains a significant challenge in transplantology, prompting efforts to maximize the use of available organs and expand the donor pool, including through extended criteria donors (ECDs). However, ECD kidney recipients often face poorer outcomes, including a higher incidence of delayed graft function (DGF), which is linked to worse graft performance, reduced long-term survival, and an increased need for interventions like dialysis. This underscores the urgent need for strategies to improve early DGF risk assessment and optimize post-transplant management for high-risk patients.

View Article and Find Full Text PDF

Improving the reliability of phthalate esters analysis in water samples by gas chromatography-tube plasma ionization-high-resolution mass spectrometry (GC-TPI-HRMS).

Talanta

April 2025

Applied Analytical Chemistry, University of Duisburg-Essen, Universitatsstr. 5, 45141, Essen, Germany; Teaching and Research Center for Separation, University of Duisburg-Essen, Universitatsstr. 5, 45141, Essen, Germany. Electronic address:

The monitoring of phthalate esters (PAEs) is challenging due to background contamination as well as the low selectivity observed when analyzing them by gas chromatography coupled to mass spectrometry (GC-MS) using electron ionization (EI). In this sense, alternative and soft ionization techniques could help to enhance the performance of the analytical determinations of PAEs in food samples. In this work, the use of a novel and soft ionization technique tube plasma ionization (TPI) has been explored to enhance the selectivity and sensitivity in the determination of PAEs in drinking water samples with GC-MS.

View Article and Find Full Text PDF

Fast Solid-Phase Exfoliation of Layered Double Hydroxides with Tunable Functionalization.

ACS Appl Mater Interfaces

December 2024

School of Science, RMIT University, Melbourne, Victoria 3000, Australia.

Article Synopsis
  • Two-dimensional layered double hydroxides (LDHs) are being explored for applications in catalysis, water treatment, and energy storage, but existing exfoliation methods face environmental and efficiency challenges.
  • A new solid-phase exfoliation technique has been successfully used to create LDH nanosheets, enhancing their stability and functionality by introducing surface functional groups and defects.
  • The improved LDH nanosheets, particularly NiFe-LDH, show excellent electrocatalytic performance with a low overpotential, showcasing the method's potential as a sustainable way to prepare and functionalize 2D materials.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!