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Factors associated with willingness to perform expedited excisional treatment for patients at high risk for cervical precancer.
Gynecol Oncol Rep
February 2025
H. Lee Moffitt Cancer Center & Research Institute, Health Outcomes and Behavior, Tampa, FL, United States.
Background: The 2019 ASCCP Risk-Based Management Consensus Guidelines prefer expedited treatment, defined as proceeding to excisional treatment without first performing colposcopic biopsy, for patients with screening results indicating a high risk of cervical precancer. In this mixed methods study, we explored clinician attitudes toward expedited treatment.
Methods: In 2021, a national sample of 671 clinicians who performed colposcopy completed surveys; a subset (n = 41) of clinicians who performed colposcopy and/or directed patient treatment completed qualitative interviews.
Highly effective batch effect correction method for RNA-seq count data.
Comput Struct Biotechnol J
December 2024
Department of Computer Science and Information Science, California State University San Marcos, 333 S. Twin Oaks Valley Rd, San Marcos, CA 92096, USA.
RNA sequencing (RNA-seq) has become a cornerstone of transcriptomics, providing detailed insights into gene expression across diverse biological conditions and sample types. However, RNA-seq data are often confounded by batch effects, systematic non-biological variations that compromise data reliability and obscure true biological differences. To address these challenges, we introduce ComBat-ref, a refined batch effect correction method designed to enhance the statistical power and reliability of differential expression analysis in RNA-seq data.
View Article and Find Full Text PDFFreshwater waterways, and species that depend on them, are threatened by urbanisation and the consequences of the urban stream syndrome. In south-east Queensland, Australia, little is known about the impacts of the urban stream syndrome on the platypus (), meaning that populations cannot be adequately managed by conservation practitioners. The aim of this study was to determine how habitat and environmental variables, related to the urban stream syndrome, influenced platypus distribution across this region.
View Article and Find Full Text PDFAntibiotic prescribing for care-home residents: a population-based, cross-classified multilevel analysis in Scotland, UK.
Age Ageing
January 2025
School of Medicine, University of Dundee, Dundee, UK.
Background: There is wide variation in antibiotic prescribing across care-homes for older people, with implications for resident outcomes and antimicrobial resistance.
Objective: To quantify variation in antibiotic prescribing and associations with resident, care-home and general practice characteristics.
Design: Population-based analyses using administrative data.
Student Violence Against Paraprofessionals in Schools: A Social-Ecological Analysis of Safety and Well-Being.
Behav Sci (Basel)
December 2024
Berkeley School of Education, University of California-Berkeley, Berkeley, CA 94720, USA.
Violence against teachers has received increasing attention worldwide, with high rates of verbal, threatening, physical, and property violence in schools. Teacher-directed violence contributes to poor mental and physical health, high rates of turnover, and diminished student achievement. Despite these findings, there is a dearth of research on violence experienced by paraprofessionals who play key roles in supporting students with the greatest learning and behavioral needs in schools.
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