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Onco-mNGS facilitates rapid and precise identification of the etiology of fever of unknown origin: a single-centre prospective study in North China.
BMC Infect Dis
December 2024
Department of Infectious Diseases, The First Hospital of China Medical University, Shenyang, 110001, China.
Objectives: Delayed diagnosis of patients with Fever of Unknown Origin has long been a daunting clinical challenge. Onco-mNGS, which can accurately diagnose infectious agents and identify suspected tumor signatures by analyzing host chromosome copy number changes, has been widely used to assist identifying complex etiologies. However, the application of Onco-mNGS to improve FUO etiological screening has never been studied before.
View Article and Find Full Text PDFPulmonary infection caused by Tropheryma whipplei: a case report and review of the literature.
J Med Case Rep
December 2024
Jiangxi Medical Center for Critical Public Health Events, The First Affiliated Hospital of Nanchang University, Nanchang, 330052, Jiangxi, People's Republic of China.
Background: Tropheryma whipplei pneumonia is an infrequent medical condition. The clinical symptoms associated with this disease are nonspecific, often resulting in misdiagnosis or missed diagnosis. Therefore, sharing and summarizing the experiences in the diagnosis and treatment of this disease can deepen global understanding and awareness of it.
View Article and Find Full Text PDFImaging Findings of an Unusual Malignant Renal Tumor in an Infant.
Cureus
November 2024
Radiology, State University of New York Upstate Medical University, Syracuse, USA.
Malignant rhabdoid tumor is a rare highly aggressive neoplasm that affects young children. It is composed of stromal and epithelial components and commonly arises from the kidney. The clinical presentation is usually nonspecific, and the common signs are palpable abdominal mass, hematuria, fever, anemia, and hypercalcemia.
View Article and Find Full Text PDFSwitch to amoxicillin-clavulanate oral therapy in urinary tract infection caused by extended-spectrum beta-lactamase-producing Escherichia coli: Assessment by chronic phase technetium-99m dimercaptosuccinic acid renal Scintigraphy images.
J Infect Chemother
December 2024
Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan.
The incidence of urinary tract infection (UTI) caused by extensive beta-lactamase-producing Escherichia coli (ESBL-EC) is increasing, including in children. However, the available oral antibiotic treatment options for ESBL-EC are limited. Herein, we report the cases of two children diagnosed with UTI caused by ESBL-EC (ESBL-UTI) who were switched from empirical intravenous antibiotics in UTI to amoxicillin-clavulanic acid (AMPC/CVA) (14:1) after the causative organism was found to be ESBL-EC.
View Article and Find Full Text PDFSequential Macular Hole Formation as a Rare Complication of Rickettsia Post Fever Retinitis.
Ocul Immunol Inflamm
December 2024
Department of Uveitis and Ocular Immunology Services, Narayana Nethralaya, Bangalore, India.
Purpose: We describe a rare complication of macular hole formation in rickettsia post-fever retinitis.
Patients And Methods: Retrospective observational case report of a patient who presented with post-fever retinitis and cystoid macular edema that later progressed to a macular hole. Clinical record and multimodal imaging including fundus photography, fundus fluorescein angiography (FFA), and spectral domain optical coherence tomography (SD-OCT) were analyzed.
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