Deep indentation and puncture can be used to characterize the large strain elastic and fracture properties of soft solids and biological tissues. While this characterization method is growing in application there are still open questions about deep indentation and puncture, including how the distribution of strains and stresses in the surrounding material relate to the resultant force exerted on the indenter. Direct quantification of the deformation field around a rigid indenter during penetration of a soft solid is necessary to substantiate the current qualitative understanding of these strains and increase the impact and usefulness of puncture tests. Here, the deformation field of a rigid cylinder inserted into a soft solid is quantified using digital image correlation (DIC). DIC measurements are validated by reconstituting the measured nominal force on the cylinder during deep indentation and puncture. The deformation field is used to map the strain field around the indenter during deep indentation and puncture. These measurements provide direct insight into the puncture process and show that while the resultant force mainly arises from the sheared region on the sides of the indenter, the compressed region below the tip is responsible for initiating failure.
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http://dx.doi.org/10.1039/d0sm01775b | DOI Listing |
Nanoscale
January 2025
State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China.
Liquid biopsies are expected to advance cancer management, and particularly physical cues are gaining attention for indicating tumorigenesis and metastasis. Atomic force microscopy (AFM) has become a standard and important tool for detecting the mechanical properties of single living cells, but studies of developing AFM-based methods to efficiently measure the mechanical properties of circulating tumor cells (CTCs) in liquid biopsy for clinical utility are still scarce. Herein, we present a proof-of-concept study based on the complementary combination of AFM and microfluidics, which allows label-free sorting of individual CTCs and subsequent automated AFM measurements of the mechanical properties of CTCs.
View Article and Find Full Text PDFJ Transl Med
January 2025
Dental School, The University of Western Australia, 17 Monash Avenue, Nedlands, WA, 6009, Australia.
Background: Treatment of deep carious lesions poses significant challenges in dentistry, as complete lesion removal risks compromising pulp vitality, while selective removal often reduces the longevity of restorations. Herein, we propose a minimally invasive approach using High-Intensity Focused Ultrasound (HIFU) for microscale removal of carious dentine. Concurrently, HIFU's antimicrobial effects against associated cariogenic biofilms and the corresponding thermal and biological impacts on surrounding tissues were investigated.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
Department Dental Clinical Sciences, Dalhousie University, 5981 University Avenue, Halifax, NS B3H 4R2, Canada.
The load and size of the indentation may affect the hardness value. This study investigated the effect of the indentation size on the microhardness of one resin-based composite (RBC). Metal molds 4 mm deep and 12 mm in diameter were filled with Tetric EvoCeram Bulk Fill (Ivoclar) and light-cured for 10 s using a broad-spectrum LED curing light.
View Article and Find Full Text PDFSci Rep
January 2025
Beijing Solidwel Intelligent Technology Co., Ltd., BeiJing, 100000, China.
Based on the Johnson-Cook constitutive model and modified Coulomb's law, the study investigates the impact of various process parameters on the weld temperature field in high-strength 5052 aluminum alloy friction stir welding (FSW) for aerospace applications. Utilizing a thermo-mechanical model, the significance of rotational speed, welding speed, and indentation on the peak weld temperature is examined through Taguchi's orthogonal experimental design. S/N ratio and ANOVA results show that the rotational speed has the most significant effect on the peak temperature of the weld, followed by the amount of indentation, and the welding speed has the smallest effect, the optimal combination of welding process parameters is determined as follows:the rotational speed is 1000 rpm, the amount of indentation is 0.
View Article and Find Full Text PDFJ Musculoskelet Neuronal Interact
December 2024
Department of Medical Imaging, St. Joseph's Health Care London, Ontario, Canada.
Anterior tarsal tunnel syndrome, an infrequent entrapment neuropathy involving the deep peroneal nerve beneath the inferior extensor retinaculum in the anterior ankle, is often overlooked on medical images, leading to delayed diagnosis and treatment. We present the case of a 52-year-old male, an avid runner, who exhibited a sensation of burning and tingling in the dorsal region of both feet. Electrophysiologic studies suggested bilateral deep peroneal neuropathy.
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