Folding paper is a seemingly simple act that requires planning, bimanual coordination, and manual strength and control to produce specific forces. Although paper folding has been used as an assessment tool and as a way to promote spatial skills, this study represents the first attempt to document when paper folding emerges across early childhood. Seventy-seven children (ages 18 months to 7 years) and an adult reference group (24 college-aged adults) completed three pre-specified folds on a single piece of paper. Dependent variables included whether children attempted each fold and, if so, the accuracy of each fold. Grip strength, pinch strength, and developmental level were examined as potential correlates of paper folding. The results demonstrated that paper folding emerges as early as 27 months of age but becomes more accurate with age. At least 50% of children between 4 and 5 1/2 years of age completed folds. Additionally, children with more age-appropriate problem-solving skills attempted more folds, independent of age. These findings provide a descriptive framework for the ages at which paper folding emerges and suggest that paper-folding interventions could be implemented at even earlier ages than what previously has been examined.
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http://dx.doi.org/10.1123/jmld.2016-0044 | DOI Listing |
J Clin Exp Neuropsychol
January 2025
Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Introduction: Sensory hypersensitivity (SHS) refers to an increased sensitivity to sensory stimuli, often leading to sensory overload and adversely affecting daily functioning and well-being. This study examined the effects of three situational triggers - noise, time pressure, and cognitive load - on task performance, sensory overload, and fatigue. Additionally, we sought to explore the associations between these effects and SHS, while accounting for other influencing factors such as personality, coping mechanisms, and anxiety.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Photostimulus-responsive fluorescent materials are promising for anticounterfeiting and UV printing due to rapid response and simple preparation. In this paper, we propose a novel strategy to prepare photostimulus-responsive materials SP@HOF-olefin by integrating the photochromic molecule spiropyran (SP) with postsynthetic modified hydrogen-bonded organic frameworks (HOF-olefin). Compared to SP@HOF, the composites SP@HOF-olefin exhibit enhanced photochromic properties, such as a fast response speed, pronounced color contrast, and exceptional fatigue resistance.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Pharmaceutical Nanotechnology Research Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India. Electronic address:
The objective of this work was to explore the Teriflunomide (TFM) -loaded chondroitin sulfate hybridized zein nanoparticles (TZCNPs) for the treatment of triple-negative breast cancer (TNBC). The particle size, PDI and %EE of optimized TZCNPs was found 208.7 ± 7.
View Article and Find Full Text PDFNeuroimage
January 2025
School of information science and technology, Northwest University, Xi'an, China. Electronic address:
Macroscale neuroimaging results have revealed significant differences in the structural and functional connectivity patterns of gyri and sulci in the primate cerebral cortex. Despite these findings, understanding these differences at the molecular level has remained challenging. This study leverages a comprehensive dataset of whole-brain in situ hybridization (ISH) data from marmosets, with updates continuing through 2024, to systematically analyze cortical folding patterns.
View Article and Find Full Text PDFBiochem Pharmacol
January 2025
Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy,. Electronic address:
Sarcoglycanopathies are rare forms of severe muscular dystrophies currently without a therapy. Mutations in sarcoglycan (SG) genes cause the reduction or absence of the SG-complex, a tetramer located in the sarcolemma that plays a protective role during muscle contraction. Missense mutations in SGCA, which cause α-sarcoglycanopathy, otherwise known as LGMD2D/R3, lead to folding defective forms of α-SG that are discarded by the cell quality control.
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