AI Article Synopsis

  • - This study investigates the roles of RBP-Jκ and CXCL11 in colon cancer by analyzing their expression levels in human colon cancer tissues and assessing their significance for patient prognosis.
  • - Increased levels of RBP-Jκ and CXCL11 were found in colon cancer samples compared to normal tissues, with both biomarkers correlating positively and relating to various negative outcomes such as poorly differentiated tumors and advanced TNM stages.
  • - The findings suggest that high expressions of RBP-Jκ and CXCL11 serve as independent prognostic indicators, indicating a higher risk for poor survival outcomes in colon cancer patients.

Article Abstract

Introduction: This study aims at exploring the expression and significance of recombination signal-binding protein for immunoglobulin kappa J region (RBP-Jκ) and C-X-C motif chemokine 11 (CXCL11) in human colon cancer tissues.

Methods: The RBP-Jκ and CXCL11 expression levels were assessed by immunohistochemistry and quantitative real-time polymerase chain reaction (qRT-PCR) in patients with colon cancer, and their prognostic significance was evaluated.

Results: Through analyzing 342 samples of colon cancer patients treated at our institution, increased expression of RBP-Jκ and CXCL11 was found in human colon cancer specimens compared with matched paratumorous normal specimens (<0.001). A positive correlation was found between RBP-Jκ expression and CXCL11 expression (<0.001). High RBP-Jκ expression was significantly associated with poorly differentiated tumors (=0.005), invasion beyond propria muscularis (=0.025), lymph node metastases (=0.005), distant metastasis (<0.001), advanced tumor-node-metastasis (TNM) stage (=0.004), and a shorter overall survival (<0.001). An increase in CXCL11 protein expression was associated with poorly differentiated tumors (=0.015), invasion beyond propria muscularis (=0.029), lymph node metastases (=0.031), distant metastasis (=0.045), advanced TNM stage (=0.026), and a shorter overall survival of patients (<0.001). In multivariate Cox regression analysis, RBP-Jκ protein expression (=0.036), CXCL11 protein expression (=0.001), differentiation (<0.001), depth of invasion (=0.009), distant metastasis (<0.001), and TNM stage (<0.001) were independent prognostic indicators of colon cancer.

Conclusion: High expression of RBP-Jκ is closely associated with high CXCL11 expression, which represents a risk factor for the poor overall survival of colon cancer patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107007PMC
http://dx.doi.org/10.2147/CMAR.S298580DOI Listing

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