Introduction: This study aims at exploring the expression and significance of recombination signal-binding protein for immunoglobulin kappa J region (RBP-Jκ) and C-X-C motif chemokine 11 (CXCL11) in human colon cancer tissues.
Methods: The RBP-Jκ and CXCL11 expression levels were assessed by immunohistochemistry and quantitative real-time polymerase chain reaction (qRT-PCR) in patients with colon cancer, and their prognostic significance was evaluated.
Results: Through analyzing 342 samples of colon cancer patients treated at our institution, increased expression of RBP-Jκ and CXCL11 was found in human colon cancer specimens compared with matched paratumorous normal specimens (<0.001). A positive correlation was found between RBP-Jκ expression and CXCL11 expression (<0.001). High RBP-Jκ expression was significantly associated with poorly differentiated tumors (=0.005), invasion beyond propria muscularis (=0.025), lymph node metastases (=0.005), distant metastasis (<0.001), advanced tumor-node-metastasis (TNM) stage (=0.004), and a shorter overall survival (<0.001). An increase in CXCL11 protein expression was associated with poorly differentiated tumors (=0.015), invasion beyond propria muscularis (=0.029), lymph node metastases (=0.031), distant metastasis (=0.045), advanced TNM stage (=0.026), and a shorter overall survival of patients (<0.001). In multivariate Cox regression analysis, RBP-Jκ protein expression (=0.036), CXCL11 protein expression (=0.001), differentiation (<0.001), depth of invasion (=0.009), distant metastasis (<0.001), and TNM stage (<0.001) were independent prognostic indicators of colon cancer.
Conclusion: High expression of RBP-Jκ is closely associated with high CXCL11 expression, which represents a risk factor for the poor overall survival of colon cancer patients.
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http://dx.doi.org/10.2147/CMAR.S298580 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
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January 2025
Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
The identification of immune environments and cellular interactions in the colon microenvironment is essential for understanding the mechanisms of chronic inflammatory disease. Despite occurring in the same organ, there is a significant gap in understanding the pathophysiology of ulcerative colitis (UC) and colorectal cancer (CRC). Our study aims to address the distinct immunopathological response of UC and CRC.
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Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.
Background: Recent research reported that cancer patients had lower risk of Alzheimer's disease (AD). Common signaling pathways, hormonal systems, and genetic predispositions have been hypothesized as important factors contributing to this inverse association. However, the exact mechanisms are still unknown.
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Paris Brain Institute, PARIS, France.
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View Article and Find Full Text PDFBr J Nutr
January 2025
Department of Community Medicine, University of Tromsø - The Arctic University of Norway, 9037 Tromsø, Norway.
Colorectal cancer, the third most common cancer globally, causes over 900,000 deaths annually. Although vitamin D is observed to have potential anti-carcinogenic properties, research findings on its preventable effect against colorectal cancer remain inconclusive. Notably, different subsites within the colon and rectum may be associated with distinct risk factors.
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